Flashcards
Antigens Recognition
Flashcards do conjunto (19)
- 1PAMP'sPathogen Associated Molecular Patterns
- 2Role of PAMP'sVital to metabolic processes of most antigens and so occur in all of them (with some variation)
- 3PRR'sPattern Recognition Receptors
- 4Role of PRR'sRecognise PAMP's - broad specificity due to PAMP variation
- 5Antibodies on B- CellsEither membrane bound or secreted (known as immunoglobulins)
- 6Specificty of B-CellsHigh- specific for one antigen
- 7T Cell ReceptorsMembrane bound Ig's specific to T cells (different shape to B-Cell antibodies)
- 8EpitopesPart of antigen recognised by Ab's - can be continuous or discontinuous
- 9DomainsBasic units of Ib's
- 10L Chain Domains2- 1 variable, 1 constant
- 11H chain Domains1 Variable, 3-4 constant
- 12—Fab Domain- can rotate & bend to aid Ag binding
- 13—Fac- can 'wag' to aid binding
- 143 Hypervariable RegionsPresent in the variable domains, which form CDR loops
- 15CDRComplimentarity Determining Regions
- 16Role of CDRSome will bind to specific antigen (though not necessarily all- some are just for recogniton, not binding)
- 17Role of Ig's- OpsonisationCoating of pathogen so phagocytes can recognise Fc's
- 18Role of Ig's- Compliment StabilisationAllows compliment to Opsonise pathogen & activates further compliment cascade
- 19Role of Ig's- NeutralisationBinds to pathogen preventing invasion & blocking action of the toxin
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- Year 2 FlashCards sobre Antigens Recognition, criado por gina_evans0312 em 09-02-2014.
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- gina_evans0312
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