gina_evans0312
Quiz by , created over 5 years ago

Year 2 Quiz on NSAIDs, created by gina_evans0312 on 01/30/2014.

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gina_evans0312
Created by gina_evans0312 over 5 years ago
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Question 1

Question
Why are some NSAIDs known as 'Traditional'?
Answer
  • They only block one COX
  • The block both COXs

Question 2

Question
Describe COX1
Answer
  • Constituative
  • Inducible
  • Membrane bound
  • Cytoplasmic

Question 3

Question
The channels of both COX1 & COX 2 are constricted to prevent incorrect substrate binding
Answer
  • True
  • False

Question 4

Question
Where do NSAIDs bind on COX 1?
Answer
  • Arg 120
  • Arg 130
  • Arg 140

Question 5

Question
Aspirin binds permenantly to the Ser 530 of COX1
Answer
  • True
  • False

Question 6

Question
Why does COX2 have a much wider channel than COX 1?
Answer
  • Val533 forces the channel to be wider
  • Ser533 forces the channel to be wider
  • Ile533 forces the channel to be wider

Question 7

Question
COX2 is inducible
Answer
  • True
  • False

Question 8

Question
The smaller channel of COX2 can be used for selective inhibition- i.e. Colecoxib
Answer
  • True
  • False

Question 9

Question
COX2 is much less responsible for inflammation than COX1
Answer
  • True
  • False

Question 10

Question
Why are selective COX2 inhibitors used on patients with G.I troubles?
Answer
  • They also repair mucus membranes
  • They have fewer side effects
  • They cannot be digested properly by healthy tracts

Question 11

Question
What is the most common side effect of NSAIDs?
Answer
  • GI troubles
  • Renal insufficiency
  • C.V disorders

Question 12

Question
Aspirin is the only NSAID thought not to cause cardiovascular disorders
Answer
  • True
  • False

Question 13

Question
Name the two NSAID side effects that contribute to cardiovascular disorders
Answer
  • Inc salt and water retention
  • Constant vasoconstriction effect endothelium

Question 14

Question
Cole/Paracoxib are traditional NSAIDs
Answer
  • True
  • False

Question 15

Question
What is the effect of Aspirin in platelets?
Answer
  • Reduced Thromboxin A2
  • Reduced Thromboxin I2
  • Reduced Thromboxin E2

Question 16

Question
The binding of aspirin lasts for the entire life of the platelet
Answer
  • True
  • False

Question 17

Question
To whom can Aspirin not be given?
Answer
  • Over 65s
  • Pregnant women
  • Children under 16

Question 18

Question
Paracetamol is anti-inflammatory but not antipyretic
Answer
  • True
  • False

Question 19

Question
The action of paracetamol is unknown
Answer
  • True
  • False

Question 20

Question
Why is paracetamol toxic to the liver in high doses?
Answer
  • Oversaturates the removal pathway
  • Causing an alternative to be used

Question 21

Question
The alternative paracetamol removal pathway causes an increase in toxic NAPQ1
Answer
  • True
  • False