Flashcards
S08.02
Flashcards do conjunto (18)
- 1metHbOxidation of Heme -> hemin
Fe3+ (ferric state) instead of Fe2+ --> cannot bind O2!!! - 2Methemoglobinemialower O2 transport
caused by nitrites, drugs - 3Mb structure8 alpha helices (75% of chain) linked by loops
nonpolar side chains make heme pocket - 4O2 binding in HbH bonding between O2 and His
- 5Hb structure4 subunits of Mb
- 6Fractional saturation of O2 (molar)
- 7Fractional saturation of O2 (pressure)Y is frac. saturation!
- 8Calculating partial pressure of a gas
- 9Higher p50 value --> ?lower O2 binding affinity
P50 is pressure of O2 needed for 50% saturation - 10Hb cooperative bindingsigmoidal curve, binding of one O2 increases affinity for more O2 binding
Dissociation decreases affinity for O2 so more is delivered - 11Mb binding curveHyperbolic, no coop binding bc binds only 1 O2 molecule
- 12p50 Mb and Hbp50 Mb: 2 torr
p50 Hb: 26 torr - 13Hb bindingCooperative --> sigmiodal! (S shaped) steep in middle
always less saturated than Mb - 14Hb delivered to tissueproportional to difference in Y
deltaY = Y artery - Y vein - 15degree of cooperativitymin: 1, max: # binding sites/ moleculle
- 16R state HbR: relaxed, Fe in plane of heme, higher O2 affinity
- 17T state HbT: tense, Fe out of plane and not as available for O2 binding
- 18O2, HbT, HbR relationO2 binds R state subunit, R and T in rapid equilibrium, and causes neighboring subunits to turn to R. breaks ion pairing between subunits
Informações
- Descrição
- FlashCards sobre S08.02, criado por Zoe Fernyhough em 06-10-2016.
- Criado por
- Zoe Fernyhough
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