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HIV virus

a virus that can cause AIDS in patients

AIDS

final phase

Second phase

First phase

chronic phase/ Clinical latency

is when the virus increases and the T cells dec.

Acute phase

Flu-like/ high inc of virus

Retro virus

structure

GP120/41

GP120: binds to both MHC 1 and coreceptors ccr5 and cxcr4

GP41: fuses virus to the cell to let in the RNA

RNA (retro)

Uses reverse transcriptase to become DNA

the integrase gets the DNA into the DNA of the host cells

the virus then assembles in the cell

the virus leave via lysis/ exocytosis/ pinching off

Enveloped virus forms due to pinching off

Enveloped Virus

DNA viruses classes

Naked Caspid

polyoma/ papilloma/ adeno/ parvo

pox/ herpes/ hepadna

RNA viruses classes

+RNA via DNA

+/- RNA

Reo

-RNA

Rhabdo/ Filo/ Orthomyxo/ paramyxo/ bunya/ arena

+RNA

(Enveloped)

Toga/Flavi/Corona

(Non-enveloped)

Picorna/Calici

Notifiable Disease

any disease that is required by law to be reported to government authorities.

List

NRTI/NNRTI antiviral

Integrase inhibitor antiviral

part of assembly is that the virus's protease cleave off large proteins

protease inhibitor

Zidovudine/ Lamivudine/ Abacavir/ Stavudine

Entry inhibitors

Enfuvirtide, binds to gp41 to prevent entry of virrus

Maraviroc, binds to ccr5 to disallow the virus to enter

CCR5 receptors are found in Macrophages/ Dendritic cells/ T cells

CXCR4 receptors are only found in T cells

Viruses that attack those receptors are R5 tropic, they usually start during the infection

viruses then proceed into X4 tropic where they attack the CXCR4 receptor

Nevirapine/ Efavirenz/ Etavirine

Raltegravir

Saquinavir/ Indinavir/ Nelfinavir/ Ritonavir