Methodology Database Resistance

67542 obs. of 9 variables

EARS-Net: antimicrobial resistance data

3478 obs. of 70 variables

Data Tidying an sorting

Removing "data quality" variable

Time variable: 2000-2018

Bacteria selection

Pseudomona aeruginosa

401 obs. of 13 variables

Time variable: 2005-2018

Variable selection

% Resistance all antibiotics; # R isolates and N isolates multiresistant

Adding consumption & Econometric indicators

EARS-Net: Antimicrobial consumption Report for 2018 (community(DDD))

WHO indicators: CHE (GDP_%); CHE(per_cap_$)

World Bank data: GDP_total; rural_pop; HDR; out_pocket_exp

Woldwide Governance Indicators: rule_law; ctrl_corrup; GOV_effect

European Regions https://www.worldatlas.com/:

401 obs. of 25 variables

Time variable: 2005-2018

Interpolation (spline method)

Adding additional R_index

Multiple linear regression based PCA: five resistance % (non-multiresistant)