null
US
Entrar
Registre-se gratuitamente
Registre-se
Detectamos que o JavaScript não está habilitado no teu navegador. Habilite o Javascript para o funcionamento correto do nosso site. Por favor, leia os
Termos e Condições
para mais informações.
Próximo
Copiar e Editar
Você deve estar logado para concluir esta ação!
Inscreva-se gratuitamente
1605290
APOE, Brain Reserve and Cognition
Descrição
undergraduate Psychology of Ageing and Dementia Mapa Mental sobre APOE, Brain Reserve and Cognition, criado por Olivia Dohren em 08-11-2014.
Sem etiquetas
psychology of ageing and dementia
undergraduate
Mapa Mental por
Olivia Dohren
, atualizado more than 1 year ago
Mais
Menos
Criado por
Olivia Dohren
mais de 9 anos atrás
11
0
0
Resumo de Recurso
APOE, Brain Reserve and Cognition
Apolipoprotein E
Gene located on chromosome 19
involved in cholesterol transportation
affect likelihood of development of CVD?
genotype determined by combination of 3 alleles
e2, e3 or e4
e2/2 = lowest risk
e2 provides protection against dementia in old age
e4/4 = highest risk
15% population prevalence of e4
e4 carriers have
smaller hippocampi
greater hippocampal atrophy over time
observed in demented and healthy individuals
greater and more diffuse activation of hippocampal, prefrontal and parietal brain areas in memory tasks
Anotações:
Bookheimer et al (2000)
are e4 individuals less efficient in processing information?
Brain Reserve
Anotações:
stern (2002) good clear review
buffers against pathological progression of dementia
individual differences in amount of reserve an individual possesses
passive
Anotações:
Stern (2002) Stern et al (1999) Tisserand et al (2001)
neuroanatomical structures deteriorate with age or disease until a threshold is breached, at which point cognitive impairment is manifest
threshold*
active
demographic or lifestyle factors contribute to reserves against deleterious consequences of ageing
process tasks in more efficient manner
Katzman (1993) - education increases synaptic density -> provides reserve against pathological progression
brain is actively attempting to cope or compensate for pathology
Anotações:
Stern (2002)
cognitive reserve vs compensation
the mind's resistance to damage of the brain
i.e. deficits in cognition may not be apparent even though damage has taken place?
hardware (brain reserve) vs software (cog reserve)
Vitamin B12
influence on brain reserve
genetic predisposition to APOE + Vitamin B = episodic memory deficits?
differences observed in cognitive reserve between e4 compared to non e4 due to vitB?
ability to digest food efficiently decreases with age - not digesting enough B12?
low levels of B12 and folate associated with lower episodic memory performance in old age
Anotações:
Calvaresi & Bryan (2001)
Antagonistic Pleiotropy
comes from evolutionary theory
does a gene confer benefits in early life but become a risk factor for disease in later life?
e.g. testosterone
e4 associated with better cognitive performance in childhood/ early adulthood but deficits in old age
suggests a pleiotropic relationship between e4 and cognition across lifespan
NO evidence in support of this
entorhinal cortex
Anotações:
see Bunce et al (2012)
e4 individuals have thinnest
variation found in young people
one of the first areas to exhibit and be severely affected by neuropathology associated with AD
Quer criar seus próprios
Mapas Mentais
gratuitos
com a GoConqr?
Saiba mais
.
Semelhante
Orações Subordinadas Adverbiais
criismoreir
16 Dicas para o Professor Criativo
Alessandra S.
As moléculas orgânicas e inorgânicas
Heres Oliveira
Substantivos
Peter Ensi
Direito Processual Civil
Joelma Silva
FCE Phrasal Verbs True or False Quiz
titaleoni
Conteúdo de Português - 6° ano
biallima6
História do Islamismo
Marcus Vital
HISTÓRIA - EUROPA MEDIEVAL, FEUDALISMO - 7º ANO
Camila Amaral
Quinhentismo
Isadora Borges
Y2 - Week 1
Natalia André
Explore a Biblioteca