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Hemostasis

Descrição

Mapa Mental sobre Hemostasis, criado por indysahota em 03-10-2013.
indysahota
Mapa Mental por indysahota, atualizado more than 1 year ago
indysahota
Criado por indysahota mais de 12 anos atrás
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Resumo de Recurso

Hemostasis
  1. Primary
    1. Platelets
      1. Abnormal function
        1. Abnormal number
          1. Sequestration
            1. Splenomegaly
            2. Increased destruction
              1. Immune
                1. ITP

                  Anexos:

                  1. Pathophysiology

                    Anotações:

                    • Anti-platelet antibodies bind to platelets. Platelets get destroyed by spleen. 
                    1. Anti-platelet antibodies
                    2. Diagnosis

                      Anotações:

                      • Diagnosis of exclusion
                      1. Diagnosis of exclusion
                      2. Presentation

                        Anotações:

                        • - Asymptomatic - Minimal bruising to severe bleeding
                        1. Asymptomatic
                          1. Mild to severe bleeding
                          2. Investigations

                            Anotações:

                            • - CBC and retics: thrombocytopenia - PT and PTT normal- Test for HIV and HCV (increased risk factors)- Blood smear: decreased platelets, giant platelets- Bone marrow biopsy: increased number of megakaryocytes
                            1. CBC and retics
                              1. Thrombocytopenia
                              2. PT and PTT
                                1. Normal
                                2. Bone marrow biopsy
                                  1. Increased number of megakaryocytes
                                  2. Blood smear
                                    1. decreased and giant platelets
                                    2. Test for HIV and HCV
                                    3. Treatment
                                  3. Non-immune
                                    1. TTP
                                      1. Pathophysiology
                                        1. Can't breakdown vWF multimers
                                          1. Congenital (ADAMST13)
                                            1. Acquired
                                          2. Presentation
                                            1. Thrombocytopenia
                                              1. Purpura
                                                1. Hx of bleeding
                                                  1. Bruising
                                                  2. MAHA
                                                    1. (L) haptoglobin
                                                      1. (H) indirect bili
                                                        1. Retics
                                                          1. (H) LDH
                                                          2. Renal failure
                                                            1. Fever
                                                              1. Neurologic symptoms
                                                                1. Confusion
                                                              2. Investigations
                                                                1. CBC and blood smear
                                                                  1. Schistocytes
                                                                    1. (L) platelets
                                                                      1. Indirect bili
                                                                        1. (H) LDH
                                                                          1. (L) haptoglobin
                                                                          2. PT amd PTT
                                                                            1. Normal
                                                                            2. Coomb's test
                                                                              1. Negative (non-immune)
                                                                              2. Renal fxn
                                                                                1. Creatinine
                                                                                  1. Urea
                                                                                2. Diagnosis
                                                                                  1. Thrombocytopenia
                                                                                    1. MAHA
                                                                                    2. Treatment
                                                                                      1. Plasmapheresis
                                                                                        1. + steroids
                                                                                        2. Plasma transfusion
                                                                                      2. HIT
                                                                                        1. HUS
                                                                                      3. Decreased production
                                                                                    3. vWD
                                                                                      1. Vascular
                                                                                      2. Secondary

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