NEPHRON

NEPHRON

1. 1.RENAL CORPUSCLE

   • made up of : GLOMELURUS [ PART OF BLOOD CAPILLARY] and BOWMAN’S CAPSULE [PART OF NEPHRON ] LOCATED IN CORTEX
   • SMALL MOLECULES [ ABSORBED ] - WATER (H2O ) - SMALL MOLECULES
   • LARGE MOLECULES [ REMAIN IN BLOOD ] - LARGE PROTEINS - BLOOD CELLS
   • Filtrate : WASTE PRODUCT + VALUABLE NUTRIENTS

2. 2. PROXIMAL CUMULUTED TUBULE

   • made up of cuboidal cell [ numerous microvilli ]
     • microvilli - increase surface are for reabsorbtion
   • reabsorbs ( ELECTROLYTES , WATER , GLUCOSE , AMINO ACIDS , POLYPEPTIDES)
   • ↑IN WASTES ↓ IN NUTRIENTS

3. 3. LOOP OF HENLE

   • DESCENDING ( THIN SEGMENT ) MADE OF SQUAMOS EPITHELIAL TISSUE
     • ↑ PERMEABLE IN WATER
     • IMPERMEABLE TO SOLUTES
     • FLUID MORE CONCENTRATED AS IT FLOWS DEEPER IN THE MEDULLA
   • ASCENDING – MADE OF CUBOIDAL EPITHELIAL CELLS
     • THIN ↑ LIMB -Na+ & Cl- PUMPED OUT OF TUBULE
     • THICK ↑ LIMB - FLUID LESS CONCENTRATED AS IT MOVES UP THE TUBULE

4. 4. DISTAL CUMULUTED TUBULE

   • MADE OF : EARLY → CUBOIDAL EPITHELIAL CELLS LATE → PRINCIPAL & INTERCALATED CELLS
     • • INTERCALATED CELLS RESPONSIBLE FOR SECRETION OF H+ • PRINCIPLE CELLS (UNDER HORMONAL CONTROL
       • ALDOSTERONE - Na+ LEVEL IN THE BLOOD ↓ ADH - DEHYDRATION
   • SECRETE - IONS ,ACIDS,DRUGS,TOXINS
   • REABSORBED - H2O , Na+ , Cl-

5. 5. COLLECTING DUCT

   • MEDULLA COLLECTING DUCT - PRINCIPAL & INTERCALATED CELLS
     • REABSORBS & SECRETES WATER AND UREA UNDER HORMONAL CONTROL
   • CORTICAL COLLECTING DUCT – PRINCIPAL CELLS
     • ALDESTERONE (√) REABSORBS Na+ SECRETES K+ & H+ ALDESTERONE (X) REABSORBS K+
     • ADH (√) REABSORBS MORE H2O

6. http://www.docenten.science.ru.nl/pklaren/42_A01/42_A01.swf

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