Addison's Disease

Addison's Disease

1. Signs

   • Hyperpigmentation
     • Result of high ACTH
   • Na+/K+ imbalance
     • Result of low aldosterone
   • Weight loss
     • Caused by low appetite
       • Result of low cortisol
   • Hypotension (aka low BP)
     • Result of low aldosterone

2. Cause

   • Autoimmune attack on adrenal cortex
     • Low aldosterone
     • Low cortisol
     • High CRH
     • High ACTH
       • Because of lack of feedback from cortisol/aldosterone

3. Treatment

   • Cortisol and aldosterone analogs

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