Sana

Sana

1. platelets

   • function
     • platelet plug
     • blood coagulation
     • hemostasis
       • include
         • endothelium
         • clotting factor
         • platelet
       • function
         • prevent excessive blood loss
           • vascular constriction
           • platelet plug
           • blood clot
   • characteristics
     • count 150k-300k
     • life span 8-12 days
       • killed by spleen macrophage
     • 1 to 4 um diamtetere
   • thrombopoiesis
     • thrombopoietin
     • il-6
     • MDGF
     • GMCSF

2. bleeding disorders

   • clotting factors
     • acquired
       • vit k def
         • increase pt and ptt
       • liver disease
         • def in all clotting factors
     • hertied
       • hemophilia
         • x-linked recessive
           • factor 8
             • emophilia A
           • factor 9
             • emophilia B
         • linical features
       • VWF disease
         • autosomal dominant
           • absence of VwF
             • PTT and bleeding time increased
             • role in
               • preventon of death of factor 8
               • platelet adhesiob
   • platelets
     • num
       • thrombovytopenia
         • decreased production
           • aplastic anemia
           • megaloblastic
         • increased destruction
           • ITP
             • igg antibody attack plarelet
               • acute ITP
                 • reveals by its onw after 6 months
               • chronic ITP
                 • 6 months or longer
           • thrombotc thrombocytopenic
             • fever
             • renal failure
             • neuro deficits
             • caused by
               • def in plasimnogen
     • acquired
       • aspirin
         • ombaxane
     • congenital
       • bernard disease
       • glanzzman disease
     • superficial bleeding
       • purpura
         • pinpoint hemoorhage
       • petechiaw
         • 3-5 mm hemoorhage
       • cchymosis
         • large bruises

3. History taking bleeding disorders

4. Blood investigation

   • bleeding time
     • 2-7 min
   • PT
     • extrinsic
       • 12-14
   • PTT
     • intrinsic
   • CBC

Imagens e arquivos do mapa