Innate Immunity: Cells

Innate Immunity: Cells

1. White Blood Cells

   • move into infected tissues and destroy infections.
   • Chemotaxis
     • chemotactic factors is part of the microorganism that releases a signal which attracts WBCs
   • Phagocytosis
     • endocytosis by neutrophils and macrophages

2. Neutrophils

   • phagocytic and first cells to enter
   • Regularly cross wall of GI tract, providing protection.

3. Macrophages

   • large phagocytic cells
   • Monocytes: leave blood and enter tissues.
     • clean blood and lymph

4. Basophils and Mast cells

   • promote inflammation when activated by innate or adaptive system
   • Basophils are motile and can enter tissues
   • Mast cells: non-motile and are in CT

5. Eosinophils

   • leave blood and enter tissues
   • reduce inflammation: breakdown chemicals produced by basophils and mast cells
   • secrete enzymes killing parasites

6. Natural Killer Cells

   • type of lymphocyte
   • lyse tumor and virus-infected cells
     • recognize a variety of cell types