Metabolic Acidosis

Metabolic Acidosis

1. Addition of acid

   • Increased H+ formation
     • Ketoacidosis
     • Lactic acidosis
     • Poisoning
       • Methanol
       • Ethanol
       • Salicylate
     • Inherited organic acidosis
   • Acid Ingestion
     • Acid poisoning
     • Arginine

2. Loss of bicarbonate

   • Diarrhoea
   • Pancreatic, intestinal or billiary fistulae/ drainage

3. H+ excretion

   • Renal tubular acidosis
   • Renal failure
   • Carbonic dehydratase inhibitors