PDD - Cardiovascular Pharmacology

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Positive inotropes:

Cardiac Glycosides

Sympathomimetrics (beta agonists) - stimulating the nervous system

Inodilators (PDE III inhiibtors and calcium sensitisers)

Beta 1-adrenergic agonists and inodilators:

works by stimulating a beta 1 receptor = increase contraction of the heart

PDE II = cardiac muscle responsible for breakdown of cAMP

Inodilator = same effect as increases cAMP

Both inhibitors increase cAMP = increase calcium and increased contraction

*positive inotropic function on the heart

ACE inhibitors act as vasodilators