Non competitive Regulation

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II. Non-competitive Regulation :

- Negative Allosteric Regulation :

involves an inhibitor molecule in which the molecules do not block the active site Instead they bind to another part of the enzyme at the allosteric site. The allosteric sites is different from enzyme active site because the binding changes the shape of the active site which stops enzymatic activity .

*** Decrease activity / inhibit enzyme

- Positive Allosteric Regulation :

Inactive form of enzyme effector binds to enzyme allowing the substrate to bind and form active enzyme

*** increases activity /enables enzyme