tissue repair

1. 1the hindbrain is the most ___ side of the nervous system

   1. Aanterior
   2. Bposterior
2. 2the forebrain is the most ___ part of the nervous system

   1. Aanterior
   2. Bposterior
3. 3the notochord...

   1. Ais underlying the entire neural tube
   2. Bis neural tissue
   3. Cis endoderm derived
   4. Dis mesoderm dervived
   5. Esecretes Shh
   6. Fis the organiser of the nervous system
   7. Gis not the organiser of the nervous system
4. 4Shh is released from

   1. Athe notochord
   2. Bthe notochord and floorplate
   3. Cthe floorplate and the somites
   4. Dthe floorplate and the ISO organiser
5. 5words: PTCH1, GLI,SMO, inactivated, signals, inhibits, activates, gradient, activated, inactivated
   complete the process of Shh signalling:
   1. Shh binds [blank_start]PTCH[blank_end] and the complex formed is inactivated
   2. [blank_start]SMO[blank_end] is released
   3. SMO signals [blank_start]GLI[blank_end]
   4. A [blank_start]gradient[blank_end] of GLI is formed
   5. Transcription factors are [blank_start]activated[blank_end]

   1. Aactivated
   2. Bgradient
   3. CPTCH
   4. DSMO
   5. EGLI
6. 6transcription factors activated by GLI

   1. APax7
   2. BNk6.1
   3. Cfgf8
   4. DOlig2+
   5. ENkx2.2
7. 7which of the following TFs is activated by a low threshold of GLI?

   1. ANkx6.1
   2. BNkx2.2
   3. COlig2+
8. 8in the ____ the floorplate makes dopaminergic neurons

   1. Amidbrain
   2. Bspinal cord
9. 9Msx2 is a marker of

   1. Athe midbrain
   2. Bthe floorplate
   3. Cthe hindbrain
   4. Dthe forebrain
10. 10In midbrain development, Nkx2.2 is the marker of the

    1. Aventral side
    2. Bdorsal side

11. 11in midbrain development, Pax7 is the marker of the

    1. Aventral side
    2. Bdorsal side
12. 12FGF8 is released by

    1. Athe ISo organiser
    2. Bthe hindbrain
    3. Cthe hidbrain
    4. Dthe forebrain
    5. Ethe floorplate of the midbrain
13. 13FGF8 + low Wnt signalling instructs

    1. Amidbrain tissue
    2. Bhindbrain tissue
14. 14FGF8 + high Wnt signalling instructs

    1. Amidbrain tissue
    2. Bhindbrain tissue
15. 15DA neurons, found in the midbrain, secrete dopamine to the

    1. Aputamen, found in the striatum
    2. Bstriatum, found in the putamen
16. 16A possible treatment for Parkinson's disease is the transplantation of DA neurons. To make DA neurons from ESCs cells, we want the cells to be as _____ as possible

    1. Aventral
    2. Bdorsal
17. 17the first step of making DA neurons from ES cells is:

    1. Acoger ES cells y ponerles dos inhibitors of SMAP for making them general neural cells
    2. Bvery high activation of Shh for making them VENTRAL
    3. Cright activation of Wnt + FGF8 for making them midbrain
18. 18midbrain cells, grown from culture, are transplantable after

    1. A16 days in culture
    2. B20 days in culture
    3. C14 days in culture
19. 19after ___ weeks of transplantation, some cellsstart to grow in the striatum

    1. A10
    2. B20
    3. C16
20. 20After ____ weeks from transplantation, cells are mature and extend to the striatum

    1. A10
    2. B20
    3. C16
21. 21After ___ week sfrom transplantation, unilateral rotation is not seen anymore

    1. A20
    2. B10
    3. C16
22. 22when cells leave the floorplate to make dopaminergic precursos, __ and ___ expression decreases

    1. ACORIN and LMX1A
    2. BCORIN and NURR1
    3. CCORIN and FGF8
    4. DCORIN and tyrosine hydroxilase
    5. Enone of the answers
23. 23in the treatment of Parkinson's with stem cells, for transplantation, we want the cells to become

    1. ADA neurons
    2. BDA neurons precursors
    3. Cgeneral neural cells
    4. Dputarium cells
24. 24The TF code of the midbrain floorplate is well-known

    1. AVerdadeiro
    2. BFalso
25. 25Nk6.1 is expressed on the midbrain floorplate

    1. AVerdadeiro
    2. BFalso
26. 26All lateral tissues from hindbrain, forebrain and mibdrain can activate DA markers

    1. AVerdadeiro
    2. BFalso
27. 27All tissues from hindbrain, forebrain and midbrain can be ventralized using the right level of Shh

    1. AVerdadeiro
    2. BFalso
28. 28ISO releases FGF8, which causes a gradient both in the anterior direction and the posterior direction

    1. AVerdadeiro
    2. BFalso
29. 29Unilateral rotation can be seen in the side that does not contain the lesion

    1. AVerdadeiro
    2. BFalso
30. 30At the spinal cord, the floorplate dies

    1. AVerdadeiro
    2. BFalso
31. 31Shh and Gli transcription factors are involved in

    1. Athe dorso-ventral patterning of the neural tube
    2. Bin the anterior-posterior patterning of the neural tube
    3. Cin the proximo-distal patterning of the neural tube
32. 32the fate of dorsal cells can be changed and they can become ventral cells

    1. AVerdadeiro
    2. BFalso

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CTO Quiz sobre tissue repair, criado por cocacola light em 26-11-2018.

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cocacola light

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