2680234
Descrição
Quiz por Becca Shaw, atualizado more than 1 year ago
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Criado por Becca Shaw
quase 9 anos atrás
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Questão 1
Questão
When a false substrate drug acts on an enzyme, an abnormal metabolite is produced. True or false?
Responda
- True
- False
Questão 2
Questão
Drugs can potentiate enzymes (i.e. increase their activity). True or false?
Responda
- True
- False
Questão 3
Questão
An inactive drug is produced when a pro-drug binds to an enzyme. True or false?
Responda
- True
- False
Questão 4
Questão
Nitric oxide stimulates what enzyme?
Responda
-
Hydroxylcarboxylase
-
Phosphatase kinase
-
Guanylate cyclase
-
Acetyloxidase
Questão 5
Questão
Drugs releasing nitric oxide (NO) are used to treat what?
Responda
-
Angina
-
Bacterial infections
-
Asthma
-
Stomach ulcers
Questão 6
Questão
Which of the following drugs inhibits cyclo-oxygenase?
Responda
-
Fluoxetine
-
Paracetamol
-
Aspirin
-
Quinine
Questão 7
Questão
Which of the following drugs inhibits phosphodiesterase?
Responda
-
Aspirin
-
Caffeine
-
Paracetamol
-
Tetracycline
Questão 8
Questão
What roles does the drug Aspirin play?
Responda
-
Anticoagulant
-
Analgesic
-
Anti-inflammatory
-
Antipyrectic
Questão 9
Questão
Aspirin is a reversible enzyme inhibitor. True or false?
Responda
- True
- False
Questão 10
Questão
What is the function of the enzyme cyclo-oxygenase?
Responda
-
Converts arachidonic acid into prostaglandins
-
Adds a phosphate group to adenine diphosphate
-
Oxidises a cyclic organic molecule
-
Removes an oxygen group form a cyclic organic molecule
Questão 11
Questão
When Aspirin inhbits cyclo-oxygenase, what cellular effects are affected?
Responda
-
Inflammation
-
Pain
-
Vascular tone (contractile activity of smooth muscle in small arteries and arterioles)
-
Platelet function (prevents bleeding)
Questão 12
Questão
Which of the following statements are true about L-DOPA (levodopa)?
Responda
-
Prevents symptoms of rigidty and tremor
-
Increases the level of dopamine in the body
-
Activates an enzyme to produce more dopamine
-
Can be used to treat Parkinson's disease
Questão 13
Questão
In Parkinson's disease, there are reduced levels of what neurotransmitter in what part of the brain?
Responda
-
Dopamine, cerebrum
-
Acetylcholine, basal ganglia
-
Dopamine, basal ganglia
-
Acetylcholine, cerebrum
Questão 14
Questão
Why can L-DOPA be used to treat Parkinson's disease?
Responda
-
It enters the peripheral nervous system
-
L-DOPA can cross the blood-brain barrier
-
L-DOPA is the immediate precursor of dopamine
-
It acts directly upon muscles to prevent symptoms of rigidity and tremor
Questão 15
Questão
Which of the following statements are true regarding the properties of L-DOPA and dopamine?
Responda
-
DOPA-decarboxylase acts upon L-DOPA to produce dopamine
-
L-DOPA and dopamine can cross the blood-brain barrier
-
Removing a carboxylic acid group from L-DOPA forms the neurotransmitter, dopamine
-
Dopamine can be used to prevent symptoms of Parkinson's disease
Questão 16
Questão
L-DOPA is administered as a medicine. Given alone, dopamine levels would increase in the brain and periphery. How may this be prevented?
Responda
-
Administer L-DOPA in very small quantities
-
Co-administering a DOPA-decarboxylase inhibitor (e.g. carbidopa)
-
Closely monitor L-DOPA levels in the body once administered
-
Co-administer with an enzyme that removes dopamine from the body
Questão 17
Questão
Carbidopa does not cross the blood brain barrier. Therefore dopamine concentrations are only increased in the brain. True or false?
Responda
- True
- False
Questão 18
Questão
Neostigmine is an example of what?
Responda
-
An anticoagulant
-
An analgesic
-
A neurotransmitter
-
An anti-cholinesterase
Questão 19
Questão
Treatment with anti-cholinesterases boosts the effects of acetylcholine. True or false?
Responda
- True
- False
Questão 20
Questão
In general anaesthesia, the action of nicotinic acetylcholine receptors is stimulated. True or false?
Responda
- True
- False
Questão 21
Questão
What effects does inhibiting cholinesterase have?
Responda
-
Prevents acetylcholine breakdown
-
Blocks the action of nicotinic acetylcholine receptors
-
Indirectly increases acetylcholine concentration
-
Displaces the receptor blocker (a competitive antagonist) from the receptor, reversing its effects
Questão 22
Questão
Which of the following statements are true regarding the disease Myasthenia gravis?
Responda
-
Muscles that control swallowing are unaffected by the disease
-
It is an auto-immune disease in which antibodies develop against the muscle nicotinic Ach receptor
-
It is treated with anti-cholinesterases to boost the action of Ach
-
Symptoms of the disease include drooping eyelids and muscle weakness
Questão 23
Questão
Ion channel blockers allow permeation. True or false?
Responda
- True
- False
Questão 24
Questão
Ion channel modulators increase/decrease opening probability. True or false?
Responda
- True
- False
Questão 25
Questão
Which of the following is false: ion channels are grouped by
Responda
-
Overall charge
-
How they open (i.e. pressure, voltage)
-
Ion selectivity
-
Their molecular structure
Questão 26
Questão
What is the function of verapamil?
Responda
-
Acts as a competitive agonist
-
Blocks calcium channels
-
Opens potassium channels
-
Inhibits nicotinic receptors
Questão 27
Questão
Calcium ion channel blockers are used to treat which of the following?
Responda
-
Hypertension
-
Angina
-
Heart failure
-
Arrythmia
Questão 28
Questão
Which of the following statements is false regarding sodium ion channel blockers?
Responda
-
Inhibits influx of sodium, preventing action potential propagation
-
Lidocaine is an example of a sodium ion channel blocker
-
Verapamil is an example of a sodium ion channel blocker
-
Sodium channel blockers act as local anasethetics
Questão 29
Questão
Transporters move ions down their electrochemical gradient. True or false?
Responda
- True
- False
Questão 30
Questão
The action of transporters requires energy from
Responda
-
ATP hydrolysis (active transport)
-
Borrowing energy from other biochemical reactions (pre-transport)
-
Utilising an existing ion gradient (co-transport)
-
Energy is not required for the action of transporters
Questão 31
Questão
Which drug blocks Na+/K+ ATPase to treat heart failure?
Responda
-
Fluoxetine
-
Lidocaine
-
Dopamine
-
Digoxin
Questão 32
Questão
Fluoxetine is an example of
Responda
-
An anticoagulant
-
An antidepressant
-
A local anaesthetic
-
An antipyretic
Questão 33
Questão
The drug Fluoxetine is an example of a Serotonin-Selective Reuptake Inhibitor (SSRI). True or false?
Responda
- True
- False
Questão 34
Questão
Treatment with Serotonin-Selective Reuptake Inhibitors (SSRIs) increases the effects of the 5HT receptor. True or false?
Responda
- True
- False
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