Coagulation and Coagulation Disorders

Descrição

Haematology and Anatomy (Coagulation) Quiz sobre Coagulation and Coagulation Disorders, criado por gina_evans0312 em 09-01-2014.
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Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312 mais de 10 anos atrás
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Resumo de Recurso

Questão 1

Questão
The Extrinsic Pathway operates on the initiating cell
Responda
  • True
  • False

Questão 2

Questão
What is the role of the Extrinsic Pathway?
Responda
  • Coagulation initiation
  • Formation of the fibrin plug
  • Activation of Factor V

Questão 3

Questão
The Intrinsic Pathway works on...
Responda
  • The endothelium
  • The vW factor
  • The platelet surface

Questão 4

Questão
The Intrinsic pathway is designed to generate thrombin bursts
Responda
  • True
  • False

Questão 5

Questão
Name the three steps of Coagulation
Responda
  • Initiation
  • Amplification
  • Propagation

Questão 6

Questão
What begins the Initiation phase?
Responda
  • Vascular injury initiates trigger factor
  • Vascular injury exposes collagen for platelets to bind
  • Vascular injury causes blood cells to lyse

Questão 7

Questão
Trigger factor activates VII, which activates smal amounts of
Responda
  • IX
  • X
  • XI

Questão 8

Questão
X & XI bind to platelets and produce small amounts of Thrombulin
Responda
  • True
  • False

Questão 9

Questão
Thrombin initiates Amplification
Responda
  • True
  • False

Questão 10

Questão
The platelets act as a surface for the assembly of what factor complexes?
Responda
  • IX & VIII
  • Prethrombinase (X & V)

Questão 11

Questão
What happens in Propogation
Responda
  • Activated platelets/complexes generate Thrombin Burst
  • Activated platelets/complexes generate Thrombulin Burst
  • Activated platelets/complexes generate Thromblin Burst

Questão 12

Questão
What two things are required for Fibrin Clot formation?
Responda
  • Fibrinogen --> Fibrin
  • F IIa
  • F III
  • F V

Questão 13

Questão
Thrombin production is the crucial step in haemostasis
Responda
  • True
  • False

Questão 14

Questão
The first step in Coagulation Disorder diagnosis is a family & drug history
Responda
  • True
  • False

Questão 15

Questão
Name the two main clinical presentation of coagulation disorders
Responda
  • Bleeding in deep tissues
  • Bleeding in joints
  • Flushed skin
  • Easy cutting of skin

Questão 16

Questão
Prethrombin Time is anassessment of the _ Pathway
Responda
  • Extrinsic
  • Instrinsic

Questão 17

Questão
Prethrombin time is expressed as an international, normalised ratio
Responda
  • True
  • False

Questão 18

Questão
Activated Partial Thromboplastin Time is an indicator of...
Responda
  • Intrinsic pathway
  • Extrinsic pathway

Questão 19

Questão
Which of the following are not Coagulation Disorder investigations?
Responda
  • Fibrinogen Assay
  • FXIII Screen
  • Thrombin Clotting Time
  • Fibin Clotting Time

Questão 20

Questão
How do you evaluate increased prethrombin time?
Responda
  • Mix with normal platelets (50:50)
  • Remove half the platelets from a sample
  • Then a Factor VII assay

Questão 21

Questão
How do you evaluate Activated Partial Thromboplastin Time (APPT)?
Responda
  • Mix with normal plasma
  • Then do a Factor VIII, IX, XI assay
  • Then a FXII assay

Questão 22

Questão
Lack o Factor X causes no symptoms
Responda
  • True
  • False

Questão 23

Questão
Factor I assay is used if bot PT and APTT is elevated
Responda
  • True
  • False

Questão 24

Questão
If both PT and APTT is normal, what is tested for?
Responda
  • Factor XIII
  • TCT
  • Factor X

Questão 25

Questão
Aquired Coagulation Deficiencies are caused by a lack of what?
Responda
  • Vit A
  • Vit B
  • Vic D
  • Vit K

Questão 26

Questão
What can cause Aquired Vit K deficiency?
Responda
  • DIC
  • Massive Transfusion Effect
  • Malabsorption

Questão 27

Questão
Vit-K deficiency can be drug induced i.e. in the case of liver disease
Responda
  • True
  • False

Questão 28

Questão
Haemophilia A is caused by what?
Responda
  • Factor VIII deficiency
  • Factor VI deficiency
  • Factor V deficiency

Questão 29

Questão
Haemophilia A is sex linked
Responda
  • True
  • False

Questão 30

Questão
Haemophilia B is a Factor IX deficiency
Responda
  • True
  • False

Questão 31

Questão
The mutations for Haemophilia A & B are found on which chromosome?
Responda
  • X
  • Y

Questão 32

Questão
How do you identify Haemophilia B?
Responda
  • Inc PT
  • Inc APTT
  • Factor IX assay

Questão 33

Questão
Von Willebrands disease is caused by a lack of factor
Responda
  • VIII
  • VII
  • VI

Questão 34

Questão
vW disease is detected by
Responda
  • FVIII Assay
  • vWF assay

Questão 35

Questão
Since many things can effect the levels of vWF, testing is difficult
Responda
  • True
  • False

Questão 36

Questão
vW disease can be qualitative or quantitative
Responda
  • True
  • False

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