Anticoagulant and Antiplatelet Drugs

Matthew Coulson
Quiz by Matthew Coulson, updated more than 1 year ago
Matthew Coulson
Created by Matthew Coulson over 2 years ago
162
1

Description

Wednesdays 2 lectures in 1 quiz.

Resource summary

Question 1

Question
Which of the following are the body's natural anticoagulants?
Answer
  • Protein C
  • Protein S
  • Protein A
  • Protein G
  • Protein M
  • Antithrombin
  • Antifibrin
  • Antiprothrombinase
  • Antithrombase
  • Antithrombomodulin

Question 2

Question
[blank_start]Heparin[blank_end] is an anticoagulant drug which binds to one of the body's naturally occurring anticoagulants and up-regulates its action
Answer
  • Heparin

Question 3

Question
Which naturally occurring anticoagulant of the body does Heparin bind to and potentiate? [blank_start]Antithrombin[blank_end]
Answer
  • Antithrombin

Question 4

Question
Which two coagulation factors can be inhibited by unfractioned Heparin bound to antithrombin?
Answer
  • Factor Ia (Fibrin)
  • Factor IIa (Thrombin)
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Question 5

Question
The difference between unfractioned Heparin and LMWH is that LMWH can only bind to one clotting factor, which is...
Answer
  • Factor Ia
  • Factor IIa
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Question 6

Question
Which monitoring test should be used to measure the action of unfractioned Heparin?
Answer
  • Prothrombin time
  • Activated Partial Thromboplastin Time (APTT)
  • Anti-Xa Assay

Question 7

Question
Heparin can induce thrombocytopenia with thrombosis in long term use.
Answer
  • True
  • False

Question 8

Question
Which of the following complications can be caused by long term Heparin use?
Answer
  • Osteoporosis
  • Hypothyroidism
  • Iron Deficiency Anaemia
  • B12 Deficiency Anaemia
  • Acute Myeloid Leukaemia

Question 9

Question
Whilst Heparin reversal is usually conducted by simply stopping the heparin (short half life), in cases of major bleeding which drug can be given to reverse the antithrombin effect of heparin?
Answer
  • Protamine Sulphate
  • IV Ferrous Fibrinase
  • Prothrombin Inducing Enzyme (PTIE)
  • Coagulating Factor III (CFIII)

Question 10

Question
Warfarin is an anticoagulant which brings about the inhibition of [blank_start]Vitamin K[blank_end]
Answer
  • Vitamin K

Question 11

Question
Which clotting factors rely on Vitamin K for carboxylation?
Answer
  • Factor II
  • Factor III
  • Factor IV
  • Factor V
  • Factor VI
  • Factor VII
  • Factor VIII
  • Factor IX
  • Factor X
  • Factor I

Question 12

Question
Warfarin administration should be conducted at the same time every day.
Answer
  • True
  • False

Question 13

Question
Which testing method is used to measure the amount of Warfarin in an individual's system? (use acronym) [blank_start]INR[blank_end]
Answer
  • INR

Question 14

Question
A normal INR is typically between
Answer
  • 2.0-3.0
  • 1.0-3.0
  • 3.0-4.0
  • 3.0-5.0

Question 15

Question
Which two of the following should be given to a patient with suspect Warfarin toxicity?
Answer
  • Vitamin K orally
  • Vitamin K intravenously
  • FFP
  • Protamine Sulphate
  • Platelet transfusion

Question 16

Question
Rivaroxaban & Apixaban are direct inhibitors of which clotting factor?
Answer
  • Factor Ia
  • Factor IIa
  • Factor IIIa
  • Factor IVa
  • Factor Va
  • Factor VIa
  • Factor VIIa
  • Factor VIIIa
  • Factor IXa
  • Factor Xa

Question 17

Question
Dabigatran is another type of new anticoagulant, providing direct inhibition of ...
Answer
  • Prothrombinase
  • Thrombin
  • Prothrombin
  • Fibrinogen
  • Fibrin
  • Factor VIIIa

Question 18

Question
In prophylaxis of elective hip/knee replacement surgery, which would be the most appropriate choice of medication?
Answer
  • Warfarin
  • LMWH
  • Apixaban

Question 19

Question
Structure of an artery from deep to superficial: Tunica Intima = [blank_start]Endothelial Cells[blank_end] Tunica Media = [blank_start]Smooth Muscle[blank_end] Tunica Externa = [blank_start]Loose Fibrous Connective Tissue[blank_end] Serosa = [blank_start]Epithelial Cells[blank_end]
Answer
  • Endothelial Cells
  • Smooth Muscle
  • Loose Fibrous Connective Tissue
  • Epithelial Cells

Question 20

Question
Atherosclerosis is damage to the endothelium resulting in plaque formation due to recruitment of 'foamy' [blank_start]macrophages[blank_end] which are rich in [blank_start]cholesterol[blank_end]
Answer
  • cholesterol
  • macrophages

Question 21

Question
Which four of the following are risk factors for arterial thrombosis?
Answer
  • Diabetes
  • Hypertension
  • Smoking
  • High HDL cholesterol
  • High LDL cholesterol
  • Atrial Fibrillation
  • Alcoholism
  • Hyperthryoidism

Question 22

Question
When there is endothelial damage, platelets bind to the subendothelial collagen via [blank_start]Glycoprotein 1b[blank_end] and [blank_start]Von Willebrand Factor[blank_end]
Answer
  • Von Willebrand Factor
  • Platelet Adhesin
  • Platelet Derived Growth Factor
  • Protein Disulfide Isomerase
  • Glycoprotein 1b
  • Platelet Membrane Glycoprotein
  • ITGA2B
  • Human Platelet Antigen

Question 23

Question
After binding to the subendothelial collagen, platelets begin to attach to each other via [blank_start]Glycoprotein IIb/IIIa[blank_end] and fibrinogen
Answer
  • Glycoprotein IIb/IIIa
  • Glycoprotein Ib
  • Platelet Derived Growth Factor

Question 24

Question
Antiplatelet drugs: Clopidogrel = [blank_start]ADP receptor Antagonist[blank_end] Aspirin = [blank_start]Cyclo-Oxygenase Inhibitor[blank_end]
Answer
  • Cyclo-Oxygenase Inhibitor
  • ADP receptor Antagonist

Question 25

Question
Antiplatelets such as Abciximab inhibit [blank_start]Glycoprotein IIb/IIIa[blank_end] thus inhibiting the [blank_start]aggregation[blank_end] stage of platelet plug formation
Answer
  • aggregation
  • adhesion
  • activation
  • Glycoprotein IIb/IIIa
  • Glycoprotein Ib
  • ADP

Question 26

Question
Antiplatelet agents should be stopped [blank_start]7[blank_end] days prior to an elective operation.
Answer
  • 7
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