Quiz
DNA Replication and Repair
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Perguntas do quiz (30)
1DNA synthesis always takes place at the [blank_start]3’ end[blank_end] of a DNA strand. This enzyme catalyzes a [blank_start]nucleophilic attack[blank_end] of the alpha phosphate by the 3’ end of the DNA, displacing the gamma and beta phosphates.
- A3’ end
- B5' end
- Cnucleophilic attack
- Delectrophillic attach
2During DNA replication, the primer-template complex and nucleotide triphosphates are bound to a DNA polymerase.
- AVerdadeiro
- BFalso
3DNA polymerase adds the correct nucleotide about 10 times more rapidly than the incorrect nucleotide.
- AVerdadeiro
- BFalso
4During DNA replication, a base pair is mismatched with the corresponding nucleotide. What event occurs to fix this problem?
- AThe mismatched nucleotide is excised from the sequence on a secondary active site on the DNA polymerase known as exonuclease.
- BThe mismatched nucleotide is excised from the sequence on a primary active site on the DNA polymerase.
- CThe mismatched nucleotide is excised from the sequence on a secondary active site on the DNA polymerase known as the topoisomerase.
- DThe mismatched nucleotide is excised from the sequence on a secondary active site on the DNA polymerase known as the helicase.
5Exonuclease is a proofreading mechanism that catalyzes cleavage of unpaired nucleotides at the [blank_start]3[blank_end]’ end.
- A3
6All DNA polymerases have the exonuclease proofreading function.
- AVerdadeiro
- BFalso
7The leading and lagging strands of DNA replication are created by DNA polymerase moving in [blank_start]opposite[blank_end] directions.
- Aopposite
8The lagging strand is synthesized by DNA polymerase in pieces, known as Okazaki Fragments.
- AVerdadeiro
- BFalso
9The leading strand [blank_start]does[blank_end] have a 3' end primer and the lagging strand [blank_start]does not[blank_end] have a 3' end primer.
- Adoes
- Bdoes not
- Cdoes not
- Ddoes
10If the lagging strand does not have a 3' end primer present, then how are the gaps filled in the lagging strand.
- APrimase
- BHelicase
- CRNAase
- DDNAase
11What are some characteristics of primase?
- AHigh error rate
- BLow error rate
- Cremoved by RNase H
- Dremoved by DNase H
- ERNA primer
- Fdoes not need primer
- Gneeds primer
12After the lagging strand is filled, what enzyme is used to fix minor kinks in the strand?
- ADNA ligase
- BDNA helicase
- CDNA topoisomerase I
- DDNA topoisomerase II
13What is the purpose of sliding clamps in DNA replication?
- AOpens the DNA helix
- BHolding DNA polymerase in place
- CFilling gaps in the DNA
- Dre-winding the DNA structure
14Along with sliding clamps, the tau-gamma complex helps keeps DNA polymerase in place.
- AVerdadeiro
- BFalso
15What is the protein that prevents the parental DNA strands from closing during replication?
- AHelicase
- BTopisomerase
- CSingle Strand Binding Protein
- DLigase
16Once DNA replication begins, the initiator complex is [blank_start]inactivated[blank_end]
- Ainactivated
- Bactivated
17Thymine dimers form what type of structure in DNA?
- ACyclobutane Ring
- BCyclopentane Ring
- CCylcohexane Ring
- DCyclopropane Ring
18In bacteria, [blank_start]MutS[blank_end] forms a “molecular clamp” that slides along double-stranded DNA until it reaches a mismatch“bubble”,
and is activated. Once activated, MutS recruits [blank_start]MutL-MutH[blank_end], a special nicking endonuclease.- AMutS
- BMutA
- CMutH
- DMutL
- EMutL-MutH
- FMutA-MutS
- GMutS
- HMutH
19What is the medical condition associated with the inability to repair mismatch DNA?
- ATurcote Syndrome
- BTurner Disease
- CLupus
- DDown Syndrom
20When a thymine dimer is formed, what is the repair mechanism that removes them?
- AExcision Repair Nucleases
- BLigase
- CExcision Repair Ligase
- DRNases
21Single nucleotide (A-G and C-T) mismatches create significant deformities in the DNA structure, so these error are repaired by excision repair nucleases.
- AVerdadeiro
- BFalso
22Mismatch repair cancer syndrome (MMRCS) is a result of a bodies inability to repair mismatched base pairs. This syndrome is categorized into:
- AHomozygous mutation (more severe)
- BHeterozygous mutation (less severe)
- CHomozygous mutation (less severe)
- DHeterozygous mutation (more severe)
23Double-stranded breaks in DNA are a result of [blank_start]ionizing radiation[blank_end], so a second chromosome is used to act as a template. The repair requires [blank_start]Homologous DNA Recombination[blank_end] with a Holliday junction.
- Aionizing radiation
- Bdeionizing radiation
- CHomologous DNA Recombination
- DRNA excision
24What is the gene associated with repairing double stranded DNA breaks?
- ABRCA2 gene
- BFBC12 gene
- Cp32 gene
- DORCA2 gene
25Mutations need to be Repaired Before the Third Round of DNA Replication.
- AVerdadeiro
- BFalso
26During the cell cycle, if there is a mutation detected the [blank_start]p53[blank_end] gene is activated. This gene will halt the cell cycle and sometimes induce apoptosis to prevent mutation from proliferating.
- Ap53
- BBRCA2
- Chc35
27Li Fraumeni Syndrome is associated with the p53 homozygous mutation. People with this mutation have an extremely high risk of developing cancer.
- AVerdadeiro
- BFalso
28Match the following diseases associated with DNA excision repair of UV damage
- AColon Cancer
- BSkin Cancer
- CBrain Cancer
- DOvarian Cancer
29Match all of the following diseases associated with single nucleotide mismatch repair:
- AColon Cancer
- BBrain Cancer
- CSkin Cancer
- DBreast Cancer
30Match all of the following diseases associated with double stranded DNA repair:
- ASkin Cancer
- BBreast Cancer
- COvarian Cancer
- DColon Cancer
Informações
- Descrição
- Sundin
- Autor
- Eric Nieto
- Idioma
- English
- Visualizações
- 26
- Etiquetas
- Avaliação
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