Quiz
Mutations
Perguntas do quiz (28)
1Point mutations affect a large region of the DNA.
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2Which of the following can cause DNA Mutations?
- AChemicals
- BRadiation
- CMedication
- DErrors in DNA Repair Mechanisms
3In eukaryotes, DNA Mutations that occur in the non-coding regions may still have an affect on the organism.
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4Most mutations occur in the DNA of germ-line cells.
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5A new mutation is only of consequence to the next generation if it occurs in germ line cells.
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6Which of the following is a direct consequence of somatic cell DNA mutation?
- ACancer
- BDiabetes
- CCushing's Syndrome
- DFatty Liver
7Ageing may be, in part, a consequence of an accumulation of somatic cell mutations.
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8Evolution depends on mutations.
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9How are gene mutations removed from population?
- AIndividuals choose not to mate with another individual carrying mutations.
- BIndividuals with mutations choose not to mate with healthy individuals.
- CMutations that have detrimental effects lower the chance of survival of that individual, a lower chance of reproduction means the genes are not inherited.
- DThe DNA splices out mutations when the foetus is developing.
10A point mutation occurring in non-coding DNA can still be lethal.
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11Which of the following is NOT a type of DNA mutation?
- AInsertion or Deletion
- BBase Substitution
- CBase Transportation
- DLarge Deletions
- EPoint Mutations
12Roughly what percentage of DNA is non-coding?
- A99%
- B95%
- C22%
- D57%
13Base Transversions involve a purine being replaced by a pyrimidine or vice versa.
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14How do base transversions affect the DNA?
- AIf a pyramidine is replaced with a purine, the DNA will fall apart.
- BIf a purine is added, the DNA will stick to the edge of the nucleolus.
- CThe DNA double helix shape will have either a bulge of dip in it.
- DThe DNA double helix will not form at all, so these are fatal mutations.
15Base Transitions can include example such as: G replacing A or T replacing C.
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16Normal base pairing involves Adenine ( a keto type ) binding with Thymine (also a keto type) with 2 hydrogen bonds.
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17Normal base pairing involves Cytosine (an amino type) binding to Guanine ( a keto type) with 3 hydrogen bonds.
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18What are Tautomeric forms of the DNA bases?
- ATau protein becomes embedded in the histone proteins.
- BKeto types are transformed into Enol groups and vice versa.
- CThey are unable to bind to anything, so the DNA cannot form.
19Low concentrations of Guanine(enol) exist, so one rare abnormal base pairing is: G(enol) with T(keto).
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20Spontaneous mutations can be caused by tautomeric forms of DNA bases. These abnormal bases exist in low concentrations, in equilibrium in the cell. In vitro studies show that what percentage of DNA bases are in the rare abnormal form?
- A0.003%
- B0.1%
- C1%
- D0.013%
21Which of the following statements concerning DNA/RNA proofreading is correct?
- ADNA Polymerase proofreads DNA and RNA in all organisms.
- BThere is no proofreading mechanism available for RNA.
- CViruses, such as influence and HIV, mutate regularly because they contain DNA polymerase, a mutagen for RNA.
22One common repair mechanism is that of Alkylation - DNA polymerase alkyl groups, removes and replaces them.
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23DNA Glycosylase removes and replaces the alkylated base.
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24What feature of the Genetic Code minimises the chance of disadvantageous and fatal mutations?
- AWe have so much non-coding DNA that we can use that are a repair template.
- BThe Degeneracy of the Genetic Code.
- CDNA cannot become mutated once you are born, all mutations occur when you are growing.
25The mutation causing sickle cell anaemia has not been removed from certain populations because is confers some resistance to...
- AHIV/AIDS in Caucasian individuals.
- BMalaria in Afro-Carribean individuals.
- CAIDS in children.
- DLung cancer in Afro-Carribean smokers.
26Nonsense mutations may lead to a truncated protein. How may this be detrimental?
- AThe protein may become shaped like a elephant's trunk and will adhere to ribosomes.
- BThe resulting protein may be missing active sites.
- CThe protein might be so small that it can become 'lost' in the cytoplasm, because it can exit the nucleus through the nuclear pores.
27Transposase is an enzyme which that promtes the jumping of short DNA sequences from one DNA molecule to another.
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28Chromosomal translocation in the Philadelphia chromosome leads to...
- AChronic Myeloid Leukaemia
- BAcute Lymphoblastic Leukaemia
- CA predisposition to Pancreatic Cancer.
- DChronic Anaemia
Informações
- Descrição
- Undergraduate Genetics and Development Quiz sobre Mutations, criado por Sophie Barrett em 20-02-2014.
- Autor
- Sophie Barrett
- Idioma
- English
- Visualizações
- 56
- Etiquetas
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