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Pharmacogenetics & Genomics

Description

Quiz on Pharmacogenetics & Genomics, created by Melanie Grynsztejn on 05/12/2017.
Melanie Grynsztejn
Quiz by Melanie Grynsztejn, updated more than 1 year ago
Melanie Grynsztejn
Created by Melanie Grynsztejn over 6 years ago
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Resource summary

Question 1

Question
Pharmacogenetics is study of inherited genetics [blank_start]difference[blank_end] in drug [blank_start]metabolic[blank_end] pathways which can affect [blank_start]individual[blank_end] responses to drugs, both in terms of therapeutic effect as well as adverse effects
Answer
  • difference
  • sameness
  • metabolic
  • pharmacokinectic
  • individual
  • ethnic group's

Question 2

Question
Nearly [blank_start]90%[blank_end] of general population have CYP2D6 functional duplication allele o [blank_start]10%[blank_end] has inactive copies of CYP2D6 = codeine has no analgesic effect o [blank_start]2-5%[blank_end] ultrarapid metabolizer
Answer
  • 90%
  • 80%
  • 70%
  • 10%
  • 20%
  • 5%
  • 2-5%
  • 5-10%
  • 10-15%

Question 3

Question
Codeine is metabolized by an enzyme that is genetically regulated called CYP2D6 in the liver that turns codeine into morphine
Answer
  • True
  • False

Question 4

Question
CYP2D6 is responsible for the metabolism of which drugs
Answer
  • Analgesics
  • BB
  • CCB
  • Antidepressants
  • Antispsychotics

Question 5

Question
The CYP2C19 metabolizes which drugs
Answer
  • Plavix (clopidogrel)
  • Coumadin (warfarin)
  • Dabigatran (Pradaxa)
  • Apixaban (Eliquis)

Question 6

Question
GeneSight Tests for
Answer
  • ADHD
  • Analgesic
  • MTHFR
  • Psychotropic
  • Anticoagulants

Question 7

Question
Genotype is
Answer
  • genetic constitution, alleles present at one locus
  • manifestation of genes
  • phenotypic differences
  • proportion of heterozygous population expressing the phenotype

Question 8

Question
Phenotype is:
Answer
  • genetic constitution, alleles present at one locus
  • manifestation of genotype
  • phenotypic differences in same genotype
  • proportion of heterozygous population expressing the phenotype

Question 9

Question
Variable expressivity is
Answer
  • genetic constitution, alleles present at one locus
  • manifestation of genotype
  • phenotypic differences in same genotype
  • proportion of heterozygous population expressing the phenotype

Question 10

Question
Penetrance is
Answer
  • genetic constitution, alleles present at one locus
  • manifestation of genotype
  • phenotypic differences in same genotype
  • proportion of heterozygous population expressing the phenotype

Question 11

Question
Autosomal dominant inheritance
Answer
  • Required one copy of gene mutation to express the associated condition
  • Phenotype is expressed in person heterozygous for a particular allele
  • Requires two copies of gene mutation (one from each parent) to manifest the condition
  • Phenotypes is expressed in person homozygous for a particular allele

Question 12

Question
Autosomal recessive:
Answer
  • Requires one copy of gene mutation to express the associated condition
  • Phenotype is expressed in person heterozygous for a particular allele
  • Requires two copies of gene mutation (one from each parent) to manifest the condition
  • Phenotypes is expressed in person homozygous for a particular allele

Question 13

Question
Breast cancer is [blank_start]5 - 10%[blank_end] hereditary
Answer
  • 5 - 10%
  • 0 - 5%
  • 10 - 15%
  • 15 - 20 %

Question 14

Question
Which a mutation in which BRCA gene has a 40% lifetime risk for ovarian cancer
Answer
  • BRCA-1
  • BRCA - 2

Question 15

Question
Tamoxifen is metabolized by
Answer
  • CYP2D6
  • CYP2CI9

Question 16

Question
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin
Answer
  • True
  • False

Question 17

Question
Amsterdam II criteria for HNPCC/Lynch Syndrome includes 3 relatives with CRC (colorectal cancer) and other HNPCC cancer in the family. Select the HNPCC cancers:
Answer
  • Hepatic
  • Colon
  • Endometrium
  • Small bowen
  • Pancreatic
  • Renal pelvis

Question 18

Question
Pharmacogenetics is the study of _________
Answer
  • germline mutations
  • x-linked mutations
  • autosomal dominant mutations
  • autosomal recessive mutations
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