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DF15 Tablet coating

Mer Scott 5 questions Updated 30 Apr 2018

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Questions in this quiz (5)

  1. 1There are 6 main reasons why we coat tablets.
    1. Protect tablet ingredients
    From [blank_start]moisture[blank_end], pH ranges, during [blank_start]transportation[blank_end], storage, etc.
    2. Mask taste of bitter drugs
    e.g. steroids are [blank_start]bitter[blank_end], polyphenols are astringent, lipids are [blank_start]bland[blank_end]. Improving taste improves patient [blank_start]compliance[blank_end]. Done via film coating with [blank_start]sweeteners or polymers[blank_end].
    3. Identification of tablets
    By [blank_start]embossing[blank_end]/scoring or using [blank_start]edible[blank_end] inks/dyes. Provides identification [blank_start]outside[blank_end] of packaging, protects from [blank_start]counterfeiting[blank_end], provides [blank_start]distinction[blank_end] from competition brands.
    4. Improving the ease of swallowing
    Difficulty swallowing, dysphagia, may be because of [blank_start]dry[blank_end] mouth caused by other condition, [blank_start]Parkinson's, Alzheimer's, stroke[blank_end], or lack of [blank_start]coordination[blank_end]. Smooth small tablets are easier to administer.
    5. Easier [blank_start]handling[blank_end] during manufacture
    6. Functional coating to give enteric coating / [blank_start]controlled release[blank_end] properties
    1. Amoisture
    2. Btransportation
    3. Cbitter
    4. Dbland
    5. Ecompliance
    6. Fsweeteners or polymers
    7. Gembossing
    8. Hedible
    9. Ioutside
    10. Jcounterfeiting
    11. Kdistinction
    12. Ldry
    13. MParkinson's, Alzheimer's, stroke
    14. Ncoordination
    15. Ohandling
    16. Pcontrolled release
  2. 2There are 3 main types of coating.
    1. FIlm coating
    - most [blank_start]popular[blank_end]
    - spray [blank_start]liquid polymer[blank_end] onto surface
    - [blank_start]2-3%[blank_end] increase in weight
    - [blank_start]single stage[blank_end] process
    - [blank_start]1-2[blank_end]h process, organic solvents used for quick drying
    - can modify for controlled release
    2. Sugar coating
    - successive application of [blank_start]sucrose[blank_end] solutions with [blank_start]colour and waxes[blank_end] for shine
    - [blank_start]30-50%[blank_end] increase in tablet weight
    - [blank_start]multi-stage[blank_end] process
    - [blank_start]8[blank_end]h+ process
    - only [blank_start]enteric[blank_end] controlled release product possible
    - [blank_start]printing[blank_end] possible
    3. Compression coating
    - based on pre-formulated tablet core
    - [blank_start]separates[blank_end] incompatible materials
    - can make modified release products
    - [blank_start]dry[blank_end] process
    1. Apopular
    2. Bliquid polymer
    3. C2-3%
    4. Dsingle stage
    5. E1-2
    6. Fsucrose
    7. Gcolour and waxes
    8. H30-50%
    9. Imulti-stage
    10. J8
    11. Kenteric
    12. Lprinting
    13. Mseparates
    14. Ndry
  3. 3Select all the tablets it would be unsafe for a patient to cut or crush.
    1. ASugar coated
    2. BEnteric coated
    3. CFunctional coated
  4. 4Multiparticulates are pellets, granules, beads or spheroids which are [blank_start]150[blank_end]micrometres to [blank_start]2-3[blank_end]mm in size. They are often [blank_start]coated[blank_end] and can be [blank_start]single or multiple[blank_end] drug formations. They are incorporated into a single dosage unit of a [blank_start]hard gel[blank_end] capsule, [blank_start]compressed[blank_end] tablet, or [blank_start]sachet[blank_end].
    The advantages of multiparticulate drug delivery systems are the [blank_start]flexibility[blank_end] of form of the final product, the stable [blank_start]shelf life[blank_end], the ability to have different coatings for different [blank_start]release profiles[blank_end], the reduced dose variation due to uniform [blank_start]gastric emptying[blank_end], and that they're able to be [blank_start]mixed with food[blank_end] for easier swallowing.
    1. A150
    2. B100
    3. C2-3
    4. D5-10
    5. Ecoated
    6. Fsingle or multiple
    7. Ghard gel
    8. Hcompressed
    9. Isachet
    10. Jflexibility
    11. Kshelf life
    12. Lrelease profiles
    13. Mgastric emptying
    14. Nmixed with food
  5. 5Fixed dose combinations are the delivery of [blank_start]2 or more[blank_end] drugs in a single dose form. This improves [blank_start]patient adherence[blank_end] by reducing [blank_start]the pill burden[blank_end] and ordering of medications is [blank_start]simplified[blank_end].
    1. A2 or more
    2. Bpatient adherence
    3. Cthe pill burden
    4. Dsimplified

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Description
PHCY211 (Formulation) Quiz on DF15 Tablet coating, created by Mer Scott on 30/04/2018.
Author
Mer Scott
Language
English
Views
11
History
Created on 30 Apr 2018 · updated on 30 Apr 2018
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