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MD14 Routes of delivery: Occular

Mer Scott 12 questions Updated 19 May 2018

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Questions in this quiz (12)

  1. 1Choose the incorrect statement.
    1. AThe sclera is tough and avascular, and the thickest layer.
    2. BThe choroid is a fatty layer under the sclera that is vascular.
    3. CThe retina is thin and light sensitive.
    4. DThe cornea adjoins the sclera and is vascular.
  2. 2[blank_start]Topical[blank_end] eye disorders: Conjunctivitis, blepharitis, dry eye, infections
    [blank_start]Anterior to lens[blank_end] disorders: Corneal infection, iritis, glaucoma, cataracts
    [blank_start]Posterior lens[blank_end] disorder: Viral retinitis
    1. ATopical
    2. BAnterior to lens
    3. CPosterior lens
  3. 3Typical ingredients in OTC ocular formulations:
    • [blank_start]Active[blank_end]: eg Pilocarpine, naphazoline
    • [blank_start]Vehicles / lubricants[blank_end]: eg Dextran, gelatin, propylene glycol
    • [blank_start]Preservatives[blank_end]: eg benzalkonium chloride, sorbic acid
    • Excipients: [blank_start]Wetting[blank_end] agents, [blank_start]buffers[blank_end] and [blank_start]tonicity[blank_end] adjusters
    1. AActive
    2. BVehicles / lubricants
    3. CPreservatives
    4. DWetting
    5. Ebuffers
    6. Ftonicity
  4. 4Choose the incorrect statement
    1. AOne of the main advantages of ocular topical delivery is that lower doses are required and it is painless.
    2. BThe main disadvantage of ocular topical delivery is that bioavailability is low.
    3. CTopical ocular delivery is effective for posterior eye segment.
  5. 5Ocular fluid or 'tears' come from the lacrimal gland which can store about [blank_start]7 microlitres[blank_end] of fluid. The tears are [blank_start]pH 6.9 - 7.4[blank_end], have a [blank_start]low[blank_end] buffer capacity, and contain [blank_start]lysozymes[blank_end]. Tears are not uniform and the tear film model shows that mucins like [blank_start]glycocalyx[blank_end] are concentrated by the corneal epithelia, and generally becomes more [blank_start]aqueous[blank_end] with soluble mucins. There is a [blank_start]lipid[blank_end] layer at the surface.
    1. A7 microlitres
    2. BpH 6.9 - 7.4
    3. Clow
    4. Dlysozymes
    5. Eglycocalyx
    6. Faqueous
    7. Glipid
  6. 6Max volume for eye = [blank_start]30 microlitres[blank_end]. Exceeding this volume causes spillage and [blank_start]loss[blank_end] of dose.
    Ionised drugs are [blank_start]more likely[blank_end] to be cleared by the aqueous tears as they are [blank_start]more soluble[blank_end].
    There is [blank_start]drainage[blank_end] via the nose to the GIT so there could be potential systemic [blank_start]side effects[blank_end], as well as this makes [blank_start]taste[blank_end] of formula a factor.
    1. A30 microlitres
    2. Bloss
    3. Cmore likely
    4. Dmore soluble
    5. Edrainage
    6. Fside effects
    7. Gtaste
  7. 7A hydrophilic drug is more likely to pass through the cornea faster than a hydrophobic drug.
    1. ATrue
    2. BFalse
  8. 8Choose the incorrect statement about conjunctival-scleral absorption.
    1. AWe must consider the loss of dose to systemic circulation due to conjunctival vasculature and large surface area.
    2. BMay be important for small, polar compounds
    3. CEye drops will have a short residence time
  9. 9Optimizing topical ocular drug delivery systems:
    1. Good corneal [blank_start]penetration[blank_end]
    2. Prolonged [blank_start]contact time[blank_end] with corneal epithelium
    3. Simple [blank_start]application[blank_end] for patient
    4. [blank_start]Non-irritating[blank_end]
    5. Appropriate [blank_start]molecular weight and properties[blank_end] for API
    1. Apenetration
    2. Bcontact time
    3. Capplication
    4. DNon-irritating
    5. Emolecular weight and properties
  10. 10Formulation strategies to improve topical ocular bioavailability:
    1. [blank_start]Decrease volume[blank_end] of instillation (<10microlitres)
    2. [blank_start]Formulate to minimise irritation[blank_end] (buffer at pH 6.9-7.4, make isotonic)
    3. I[blank_start]ncrease retention time[blank_end] (viscosity enhancing polymers, thixotropic rheological properties, gel formation)
    1. ADecrease volume
    2. BFormulate to minimise irritation
    3. Cncrease retention time

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Description
PHCY211 (Medicines) Quiz on MD14 Routes of delivery: Occular, created by Mer Scott on 19/05/2018.
Author
Mer Scott
Language
English
Views
6
History
Created on 19 May 2018 · updated on 19 May 2018
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