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MD21 Implantable Drug Delivery Systems (IDDS)

Mer Scott 8 questions

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  1. 1IDDS are useful for drugs that [blank_start]cannot be delivered[blank_end] via the oral route, drugs that are [blank_start]irregularly absorbed[blank_end] via the gastrointestinal tract, or drugs that benefit from [blank_start]site-specific[blank_end] dosing(examples include steroids, chemotherapeutics, antibiotics, analgesics, and contraceptives.) Because of site specificity, [blank_start]lower[blank_end] doses can be used and therefore less [blank_start]side effects[blank_end] are experienced. IDDS also improve patient [blank_start]compliance[blank_end].
    1. Acannot be delivered
    2. Birregularly absorbed
    3. Csite-specific
    4. Dlower
    5. Eside effects
    6. Fcompliance
  2. 2IDDS potential drawbacks:
    • Require [blank_start]minor surgery[blank_end]
    • [blank_start]Cost/benefit[blank_end] ratio
    • May require [blank_start]specialized training[blank_end]
    • Regulatory path for approval [blank_start]longer[blank_end]
    • [blank_start]Pain[blank_end] and discomfort
    1. Aminor surgery
    2. BCost/benefit
    3. Cspecialized training
    4. Dlonger
    5. EPain
  3. 3Polymers are used for IDDS because they are easily fabricated, have easily tuned degradation kinetics, and are biocompatible.
    1. ATrue
    2. BFalse
  4. 4Non-degradable IDDS include the matrix (diffusion) controlled system and the membrane enclosed reservoir system.
    The matrix system involves a polymer containing drug, with [blank_start]pores[blank_end], that swells /expands [blank_start]uniformly[blank_end]. This allows drug to [blank_start]diffuse[blank_end] from pores.
    The reservoir system involves a compact polymer matrix [blank_start]core[blank_end] with drug surrounded by a non-degradable semi-permeable [blank_start]membrane[blank_end]. Swelling of the membrane barrier is [blank_start]non-uniform[blank_end] and allows for water to permeate in and drug components to diffuse out. Thickness and permeability properties can
    control drug diffusion into the body.
    1. Apores
    2. Buniformly
    3. Cdiffuse
    4. Dcore
    5. Emembrane
    6. Fnon-uniform
  5. 5Membrane enclosed reservoirs can be used for many things. Which of these are they not typically used for?
    1. ABirth control (eg IUD)
    2. BVascular disease (eg drug eluting stent)
    3. COccular treatment (eg pilocarpine ring)
    4. DAnalgesia (eg ibuprofen insert)
  6. 6In biodegradable IDDS drug is [blank_start]homogeneously[blank_end] mixed within a biodegradable polymer, which is subsequently moulded into a shape. The advantages of biodegradable IDDS is that there is [blank_start]no need for removal surgery[blank_end], as the degraded [blank_start]metabolites[blank_end] are safely [blank_start]excreted or absorbed[blank_end] by the body. The polymers in these IDDS have [blank_start]labile[blank_end] bonds.
    Typically, [blank_start]hydrolysis[blank_end] of the polymer causes drug release. Controlled release of the drug is achieved by the combination of [blank_start]polymer erosion[blank_end] (by hydrolysis) and [blank_start]diffusion of the drug[blank_end] through the polymer matrix.
    The rate of drug release is determined by a) the rate of [blank_start]biodegradation[blank_end], b) polymer composition [blank_start]molecular weight[blank_end], c) drug [blank_start]loading[blank_end], and d) the drug polymer [blank_start]interactions[blank_end].
    1. Ahomogeneously
    2. Bno need for removal surgery
    3. Cmetabolites
    4. Dexcreted or absorbed
    5. Elabile
    6. Fhydrolysis
    7. Gpolymer erosion
    8. Hdiffusion of the drug
    9. Ibiodegradation
    10. Jmolecular weight
    11. Kloading
    12. Linteractions
  7. 7Biodegradable Surface Erosion: degrades from the [blank_start]outer surface[blank_end] inward, uniformly.
    Biodegradable Surface Erosion: degrades or deforms uniformly throughout the [blank_start]bulk[blank_end] of the material.
    1. Aouter surface
    2. Bbulk
  8. 8Examples of biodegradable system IDDS for [blank_start]cancer treatments[blank_end]
    • [blank_start]Gliadel[blank_end] wafer (to improve success and life expectancy after [blank_start]glioma[blank_end] removal in brain)
    • [blank_start]Zoladex[blank_end] (advanced [blank_start]prostate and breast[blank_end] cancer, releases hormones)
    1. Acancer treatments:
    2. Bglioma
    3. CGliadel
    4. DZoladex
    5. Eprostate and breast

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Description
PHCY211 (Medicines) Quiz on MD21 Implantable Drug Delivery Systems (IDDS), created by Mer Scott on 22/05/2018.
Author
Mer Scott
Language
English
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