Quiz
MD23 Oral dosage forms III
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Questions in this quiz (8)
1Advatanges of controlled release:
• Frequency of dosing [blank_start]reduced[blank_end] (improve patient [blank_start]compliance[blank_end] especially for [blank_start]chronic[blank_end] conditions)
• Improve residence time for drugs with short [blank_start]half lives[blank_end]
• Optimise release conditions to maintain [blank_start]drug stability[blank_end]
• Mimic IV infusion with a more zero order, [blank_start]uniform release[blank_end] and effect- Areduced
- Bcompliance
- Cchronic
- Dhalf lives
- Edrug stability
- Funiform release
2Monolithic matrix systems - diffusion controlled release:
1. Lipid matrix
Drug in [blank_start]solid, hydrophobic[blank_end] matrix. Channelling [blank_start]agents[blank_end] allow water in, and drug to [blank_start]diffuse[blank_end] out. Higuchi release profile.
2. Insoluble polymer matrix
Drug is dissolved or dispersed in a [blank_start]porous insoluble polymer[blank_end] matrix.
3. Hydrophilic matrix
Water soluble drug in [blank_start]swellable polymer[blank_end]. Two diffusion steps ([blank_start]water in and drug out)[blank_end]. Gel formation, then gel [blank_start]erosion[blank_end].- Asolid, hydrophobic
- Bagents
- Cdiffuse
- Dporous insoluble polymer
- Eswellable polymer
- Fwater in and drug out)
- Gerosion
3Mixed size particles with variable coating thickness contribute to a steady release profile.
- ATrue
- BFalse
4Choose the incorrect statement about the mucous later of the GIT.
- AMade up of glycoproteins
- B95% water by weight
- CPositively charged at physiological pH
- DMucus turnover 50 - 250 min
5A mucoadhesive delivery system increases absorption because it avoids enzyme degradation.
- ATrue
- BFalse
6If the pH is higher than the drug pKa they will adhere together strongly.
- ATrue
- BFalse
7Site-specific delivery is advantageous when the drug has a [blank_start]narrow[blank_end] therapeutic window, is [blank_start]unstable[blank_end] in the GIT, or [blank_start]local[blank_end] delivery is needed.
- Methods of site-specific delivery for the stomach(<[blank_start]7mm[blank_end] evacuated and
>[blank_start]15mm[blank_end] prolongs retention):
1. Superporous hydrogel
Fast, [blank_start]super swelling[blank_end] system that is mechanically [blank_start]strong[blank_end] but biodegradable over time.
2. Expandable systems
Many types eg [blank_start]accordion[blank_end] pill for levodopa release to treat Parkinson's.- Anarrow
- Bunstable
- Clocal
- D7mm
- E15mm
- Fsuper swelling
- Gstrong
- Haccordion
8We may want to give site-specific drug delivery to the colon to treat colon cancer, Crohn's disease, or ulcerative colitis. The colon has a small ([blank_start]0.2 metres squared[blank_end]) surface area, a [blank_start]wide[blank_end] lumen, and no [blank_start]villi[blank_end]. However in the colon drugs will have a [blank_start]prolonged[blank_end] residence time, there are [blank_start]reduced[blank_end] enzyme secretions, and it is responsive to [blank_start]absorption enhancers[blank_end]. It may be possible to use [blank_start]cleavage[blank_end] release by utilising the enzymes specific to colon [blank_start]bacteria[blank_end]. [blank_start]Prodrugs[blank_end] are therefore a viable option. Must be cautious when co-administering with [blank_start]antibiotics[blank_end] which could kill gut microflora.
- A0.2 metres squared
- Bwide
- Cvilli
- Dprolonged
- Ereduced
- Fabsorption enhancers
- Gcleavage
- Hbacteria
- IProdrugs
- Jantibiotics
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- PHCY211 (Medicines) Quiz on MD23 Oral dosage forms III, created by Mer Scott on 24/05/2018.
- Author
- Mer Scott
- Language
- English
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