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MD30 Systemic availability

Mer Scott 12 questions

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  1. 1Bioavailability — historic term: “A measure of the [blank_start]rate and extent[blank_end] of drug absorption, that quantifies the [blank_start]amount[blank_end] of drug that reaches the [blank_start]systemic[blank_end] circulation”. By referring to drug absorption, it implies that we can ignore [blank_start]first pass metabolism[blank_end], which we can't.
    Systemic availability "F" — "The [blank_start]fraction[blank_end] of a dose that reaches the systemic circulation." Applicable to [blank_start]any[blank_end] administration route but ignores [blank_start]rate[blank_end].
    1. Arate and extent
    2. Bamount
    3. Csystemic
    4. Dfirst pass metabolism
    5. Efraction
    6. Fany
    7. Grate
  2. 2Parameters for the [blank_start]extent[blank_end] of drug absorption:
    [blank_start]Cmax[blank_end] - Maximum observed concentration
    [blank_start]AUC[blank_end] - Area under the concentration-time curve

    Parameters for the [blank_start]rate[blank_end] of drug absorption:
    [blank_start]Tmax[blank_end] - Time that the maximum concentration (Cmax) is observed
    [blank_start]Ka[blank_end] - Absorption rate constant
    1. Aextent
    2. BCmax
    3. CAUC
    4. Drate
    5. ETmax
    6. FKa
  3. 3Absolute bioavailability (F) is the ratio of the AUC in the [blank_start]systemic circulation[blank_end] after oral ingestion, and the AUC from [blank_start]intravenous dosing[blank_end]. Oral bioavailability is [blank_start]less[blank_end] due to first pass metabolism.
    To calculate the dose that reaches the systemic circulation from an oral dose we multiply the [blank_start]oral dose[blank_end] by [blank_start]F[blank_end].
    In theory, you might need to give a [blank_start]bigger[blank_end] oral dose to achieve the same drug exposure (AUC) as [blank_start]intravenous[blank_end] dosing.

    1. Asystemic circulation
    2. Bintravenous dosing
    3. Cless
    4. Doral dose
    5. EF
    6. Fbigger
    7. Gintravenous
  4. 4Relative bioavailability refers to a case where the intravenous dose is [blank_start]not the comparator[blank_end].
    Requirements for a comparison of AUC’s:
    1. Same [blank_start]drug and dose[blank_end]
    2. [blank_start]Clearance[blank_end] must not change between the comparators
    3. Linear pharmacokinetics (AUC is [blank_start]proportional[blank_end] to dose)
    4. No other factors alter drug [blank_start]bioavailability[blank_end] (food, drug interactions)
    1. Anot the comparator
    2. Bdrug and dose
    3. CClearance
    4. Dproportional
    5. Ebioavailability
  5. 5There are three primary determinants of bioavailability;
    1. [blank_start]Disintegration and dissolution[blank_end] of the drug
    2. [blank_start]Absorption[blank_end] across the membranes in the gut wall
    3. Pre-systemic [blank_start]metabolism[blank_end] (or ‘first-pass’) and [blank_start]elimination[blank_end]
    1. ADisintegration and dissolution
    2. BAbsorption
    3. Cmetabolism
    4. Delimination
  6. 6Choose the correct equation.
    1. AF = fa / fh
    2. BF = fa x fh
    3. CF = fh / fa
  7. 7Mechanisms for first pass elimination:
    1. Metabolism in the [blank_start]gut wall[blank_end] (e.g. oestrogens, atorvastatin)
    2. [blank_start]Efflux[blank_end] from the gut wall (e.g. dabigatran)
    3. [blank_start]Esterase[blank_end] metabolism in the plasma of the [blank_start]portal circulation[blank_end] (e.g. aspirin)
    4. Metabolism in the [blank_start]liver[blank_end] (most common)
    1. Agut wall
    2. BEfflux
    3. CEsterase
    4. Dportal circulation
    5. Eliver
  8. 8Pre-systemic drug interactions impact peak plasma concentration (Cmax) not clearance.
    1. ATrue
    2. BFalse
  9. 9P-gps are responsible for gut wall efflux.
    1. ATrue
    2. BFalse
  10. 10High E by the liver means low fh.
    1. ATrue
    2. BFalse

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Description
PHCY211 (Medicines) Quiz on MD30 Systemic availability, created by Mer Scott on 27/05/2018.
Author
Mer Scott
Language
English
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