Intro To Haematology & Normal Red Cells

Matthew Coulson
Quiz by Matthew Coulson, updated 10 months ago
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Description

Intro To Haematology & Normal Red Cells 2 lectures in this one quiz

Resource summary

Question 1

Question
Between months 3-7 of pregnancy, the foetus uses which organ to conduct haematopoiesis? The [blank_start]Spleen[blank_end]
Answer
  • Spleen

Question 2

Question
A Multipotent Haematopoietic Stem Cell (Hemocystblast) can differentiate to form two types of common progenitor stem cells: The Common [blank_start]Myeloid[blank_end] Progenitor, which goes on to form such cells as neutrophils, basophils and erythrocytes. The Common [blank_start]Lymphoid[blank_end] Progenitor, which goes on to form such cells as natural killer cells, B cells and T cells.
Answer
  • Lymphoid
  • Myeloid

Question 3

Question
An erythrocyte is another term for a [blank_start]red blood cell[blank_end]. Erythrocytes arise from Common [blank_start]Myeloid[blank_end] Progenitor Cells
Answer
  • Myeloid
  • red blood cell

Question 4

Question
During erythropoiesis, the late normoblast matures by losing which of its internal structures? Its [blank_start]nucleus[blank_end]
Answer
  • nucleus

Question 5

Question
Immature, non-nucleated red blood cells are called [blank_start]reticulocytes[blank_end]
Answer
  • reticulocytes

Question 6

Question
A [blank_start]megakaryocyte[blank_end] is a large bone marrow cell with a lobulated nucleus which is responsible for the production of platelets
Answer
  • megakaryocyte

Question 7

Question
Megakaryocytes (and thus platelets) arise from common [blank_start]myeloid[blank_end] progenitor cells.
Answer
  • myeloid

Question 8

Question
Name the three types of granulocytes in alphabetical order [blank_start]Basophils[blank_end] [blank_start]Eosinophils[blank_end] [blank_start]Neutrophils[blank_end]
Answer
  • Basophils
  • Eosinophils
  • Neutrophils

Question 9

Question
[blank_start]Neutrophils[blank_end] - Granulocytes with polymorphic (multiple) nuclei [blank_start]Eosinophils[blank_end] - Granulocytes with bi-lobed nucleus [blank_start]Basophils[blank_end] - Granulocytes with large deep purple granules obscuring the nucleus
Answer
  • Neutrophils
  • Eosinophils
  • Basophils
  • Eosinophils
  • Neutrophils
  • Basophils
  • Basophils
  • Neutrophils
  • Eosinophils

Question 10

Question
Name the granulocytes.
Answer
  • Neutrophil
  • Eosinophil
  • Basophil

Question 11

Question
What is this cell type? Hint: Note the vacuoles.
Answer
  • Monocyte

Question 12

Question
Monocytes circulate in the blood for around a week before entering tissues to become [blank_start]macrophages[blank_end]
Answer
  • macrophages

Question 13

Question
Which bony aspect of the hip is the most common site for bone marrow aspiration? The [blank_start]posterior iliac crest[blank_end]
Answer
  • posterior iliac crest

Question 14

Question
Which aspect of the iliac crests, anterior or posterior, is the most common site for bone marrow aspiration? The [blank_start]Posterior[blank_end] Iliac Crests
Answer
  • Posterior

Question 15

Question
A bone marrow biopsy is also commonly called a [blank_start]trephine[blank_end] biopsy due to the surgical instrument used to conduct the procedure, which has a cylindrical saw used for removing a disk of bone.
Answer
  • trephine

Question 16

Question
Red blood cells have large, single nuclei.
Answer
  • True
  • False

Question 17

Question
Adult Haemoglobin consists of two [blank_start]alpha[blank_end] chains and two [blank_start]beta[blank_end] chains
Answer
  • alpha
  • delta
  • beta
  • gamma

Question 18

Question
Foetal Haemoglobin consists of two [blank_start]alpha[blank_end] chains and two [blank_start]gamma[blank_end] chains
Answer
  • alpha
  • delta
  • gamma
  • beta

Question 19

Question
[blank_start]Gamma[blank_end] chains allow a higher affinity for oxygen as they do not interact as well with 2,3-DPG
Answer
  • Gamma
  • Alpha
  • Beta
  • Delta

Question 20

Question
[blank_start]Fe3+[blank_end] = Oxidised form of iron [blank_start]Fe2+[blank_end] = Reduced (non-oxidised) form of Iron
Answer
  • Fe3+
  • Fe2+
  • Fe2+
  • Fe3+

Question 21

Question
The form of iron that exists in the Heme group is the [blank_start]non-oxidised[blank_end] [blank_start]Fe2+[blank_end] form
Answer
  • non-oxidised
  • oxidised
  • Fe2+
  • Fe3+

Question 22

Question
Red Blood Cell destruction occurs in which organ? The [blank_start]Spleen[blank_end]
Answer
  • Spleen

Question 23

Question
The heme group of the red blood cell is broken down by the spleen into Iron and [blank_start]Bilirubin[blank_end]
Answer
  • Bilirubin

Question 24

Question
Which organ conjugates bilirubin? The [blank_start]Liver[blank_end]
Answer
  • Liver

Question 25

Question
Bilirubin is excreted within which substance, which gives colour to both urine and faeces? The [blank_start]Bile[blank_end]
Answer
  • Bile

Question 26

Question
Heme breakdown pathway: Heme --> [blank_start]Porphyrin[blank_end] --> [blank_start]Biliverdin[blank_end] --> [blank_start]Unconjugated Bilirubin[blank_end]
Answer
  • Porphyrin
  • Biliverdin
  • Unconjugated Bilirubin

Question 27

Question
Which hormone regulates the differentiation and proliferation of erythroid progenitor cells in the bone marrow to mature red blood cells? [blank_start]Erythropoietin[blank_end]
Answer
  • Erythropoietin

Question 28

Question
Erythropoietin is produced mainly in the [blank_start]kidneys[blank_end]
Answer
  • kidneys

Question 29

Question
Methemoglobin is the non-oxygen carrying type of haemoglobin in which the heme groups contains the [blank_start]oxidised[blank_end] [blank_start]Fe3+[blank_end]
Answer
  • oxidised
  • non-oxidised
  • Fe3+
  • Fe2+

Question 30

Question
Superoxide to Hydrogen Peroxide is regulated by which enzyme? [blank_start]Superoxide Dismutase[blank_end]
Answer
  • Superoxide Dismutase

Question 31

Question
Which antioxidant reacts with Hydrogen Peroxide to form water, in order to protect us against the free radical? [blank_start]Glutathione[blank_end]
Answer
  • Glutathione

Question 32

Question
CO2 Transport: 10% [blank_start]Dissolved in solution[blank_end] 30% [blank_start]Bound directly to Hb[blank_end] 60% [blank_start]Travels as Bicarbonate[blank_end]
Answer
  • Travels as Bicarbonate
  • Bound directly to Hb
  • Dissolved in solution

Question 33

Question
[blank_start]Myoglobin[blank_end] follows Michaelis-Menten Kinetics [blank_start]Haemoglobin[blank_end] DOES NOT follow Michaelis-Menten Kinetics
Answer
  • Haemoglobin
  • Myoglobin
  • Myoglobin
  • Haemoglobin

Question 34

Question
The product of the Rapapoport-Lubering Shunt is ...
Answer
  • 2,3-DPG
  • Glutathione
  • Pentose Phosphate
  • Hexose Monophosphate
  • Glyceraldehyde-3-Phosphate

Question 35

Question
As 2,3-DPG concentration increases, the rate of oxygen dissociation [blank_start]increases[blank_end] as the affinity of haemoglobin for oxygen [blank_start]decreases[blank_end].
Answer
  • decreases
  • increases
  • increases
  • decreases

Question 36

Question
The causes of a right shift to the Oxygen–hemoglobin dissociation curve: [blank_start]Increase[blank_end] in CO2 concentration [blank_start]Decrease[blank_end] in pH [blank_start]Increase[blank_end] in 2,3-DPG concentration [blank_start]Increase[blank_end] in Exercise [blank_start]Increase[blank_end] in Temperature
Answer
  • Increase
  • Decrease
  • Decrease
  • Increase
  • Increase
  • Decrease
  • Increase
  • Decrease
  • Increase
  • Decrease

Question 37

Question
Glutathione is replenished by which chemical? Hint: It is a normal part of glycolysis [blank_start]NADPH[blank_end]
Answer
  • NADPH
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