Myeloproliferative Disorders

Matthew Coulson
Quiz by Matthew Coulson, updated more than 1 year ago
Matthew Coulson
Created by Matthew Coulson about 2 years ago
323
1

Description

Chronic Myeloid Leukaemia, Polycythaemia Rubra Vera, Essential Thrombocythaemia and Idiopathic Myelofibrosis

Resource summary

Question 1

Question
Philadelphia Chromosome is most associated with which form of Leukaemia? [blank_start]Chronic Myeloid Leukaemia[blank_end]
Answer
  • Chronic Myeloid Leukaemia

Question 2

Question
Chronic Myeloid Leukaemia is fatal without stem cell/bone marrow transplantation in the chronic phase
Answer
  • True
  • False

Question 3

Question
Which of the following conditions can in some cases present as Gout?
Answer
  • Acute Myeloid Leukaemia
  • Acute Lymphoblastic Leukaemia
  • Chronic Lymphoblastic Leukaemia
  • Chronic Myeloid Leukaemia

Question 4

Question
Which of the following would describe findings fitting with a diagnosis of Chronic Myeloid Leukaemia?
Answer
  • Neutrophilia, Eosinophilia, Basophilia, Thrombocytosis
  • Neutropenia, Eosinopenia, Basopenia, Thrombocytopenia

Question 5

Question
[blank_start]Chronic Myeloid Leukaemia[blank_end] - Causes a drastic rise in erythrocytes, platelets, neutrophils, etc [blank_start]Acute Myeloid Leukaemia[blank_end] - Causes a drastic fall in erythrocytes, platelets, neutrophils, etc
Answer
  • Acute Myeloid Leukaemia
  • Chronic Myeloid Leukaemia

Question 6

Question
Philadelphia Chromosome causes expression of a new gene encoding a protein kinase. Which of the following protein kinase inhibitors can be used to successfully treat Chronic Myeloid Leukaemia?
Answer
  • Tyrosine Kinase Inhibitors
  • Protein Kinase A Inhibitors
  • Protein Kinase G Inhibitors
  • Protein Kinase C Inhibitors
  • Tyramine Kinase Inhibitors

Question 7

Question
The main tyrosine kinase inhibitor used to treat chronic myeloid leukaemia is called [blank_start]Imatinib[blank_end]
Answer
  • Imatinib

Question 8

Question
A patient presents to their GP complaining of headache, fatigue and an intense itching which only ever occurs whilst in the bath or shower. Their blood results show high haemoglobin levels accompanied by erythrocytosis (increase in circulating RBCs). What is your working diagnosis? [blank_start]Polycythaemia Rubra Vera[blank_end]
Answer
  • Polycythaemia Rubra Vera

Question 9

Question
The presence of a JAK2 mutation in a patient would immediately lead you to thinking of which Myeloproliferative disorder? [blank_start]Polycythaemia Rubra Vera[blank_end]
Answer
  • Polycythaemia Rubra Vera

Question 10

Question
The main treatment for polycythaemia rubra vera is regular [blank_start]venesection[blank_end]
Answer
  • venesection

Question 11

Question
The treatment for Polycythaemia Rubra Vera is venesection until the haematocrit falls below [blank_start]0.45[blank_end]
Answer
  • 0.45
  • 0.55
  • 0.65
  • 0.35

Question 12

Question
An uncontrolled production of abnormal platelets is known as Essential [blank_start]Thrombocythaemia[blank_end]
Answer
  • Thrombocythaemia

Question 13

Question
Essential Thrombocythaemia causes excessive bleeding problems
Answer
  • True
  • False

Question 14

Question
Teardrop-shaped Red Blood Cells in the peripheral blood is characteristic of which Myeloproliferative Disorder?
Answer
  • Idiopathic Myelofibrosis
  • Essential Thrombocythaemia
  • Polycythaemia Rubra Vera

Question 15

Question
Idiopathic [blank_start]Myelofibrosis[blank_end] is a condition in which the proliferation of an abnormal clone of a hematopoietic stem cell results in fibrosis, or the replacement of bone marrow with scar tissue
Answer
  • Myelofibrosis

Question 16

Question
Myelofibrosis typically results in hepatomegaly
Answer
  • True
  • False

Question 17

Question
What is the first line treatment for essential thrombocythaemia?
Answer
  • Interferon Gamma
  • Interferon Beta
  • Hydroxycarbamide
  • Aspirin
  • Clopidogrel

Question 18

Question
Which of the following can be used as a secondary therapy for Essential Thrombocythaemia?
Answer
  • Interferon Gamma
  • Interferon Alpha
  • Interferon Beta

Question 19

Question
Chronic Haemolysis predisposes an individual to gallstones
Answer
  • True
  • False

Question 20

Question
Chronic haemolysis predisposes to gallstones as there are raised levels of [blank_start]bilirubin[blank_end] in the blood
Answer
  • bilirubin
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