Quiz
The Extracellular Matrix
Create a free account to finish this quiz
Save your progress and see your final score.
Already have an account? Sign in
Questions in this quiz (37)
1What are the two main components of extracellular matrix?
- AGlycoproteins and proteoglycans
- BFibrous proteins
- CFibroblast cells
- DPhospholipids
2Which of the following fibrous proteins are found in the extracellular matrix?
- ACollagen
- BElastin
- CKertain
- DActin
- EDystrophin
3The extracellular matrix does not contain any cells. True or false?
- ATrue
- BFalse
4What is the main function of collagen?
- AHigh tensile strength
- BHigh compressional strength
- CHigh hydrostatic pressure
- DWater solubility
5What tissue within the body contains the most collagen?
- ATendons
- BSkin
- CLungs
- DBone
- ECornea
6The structural organisation of collagen is always the same. True or false?
- ATrue
- BFalse
7What shape does collagen form within tendons and ligaments?
- AParallel bundles
- BSpirals
- CMeshwork
8What shape does collagen form within bone?
- ASpirals
- BParallel bundles
- CMeshwork
9What shape does collagen form within cartilage?
- AMeshwork
- BSpirals
- CParallel bundles
10What is collagen's secondary structure?
- AAlpha helix
- BBeta sheet
11What type of helix does collagen typically form?
- ADouble helix
- BTriple helix
- CCompact helix
- DReverse helix
12What is notable about collagen's primary structure?
- AIt has a three amino acid repeat with glycine every third amino acid
- BIt never repeats a particular sequence of amino acids
- CIt only contains two types of amino acid
- DIt only contains amino acids with a phenyl ring
13How is type IV collagen different to the other types of collagen?
- AIt does not have regular glycines so it forms a loose helix
- BIt is water soluble
- CIt is not found within cartilage
- DIt is coded for by a gene in a different gene cluster
14Why does collagen found within cells have frayed ends?
- ATo prevent it joining with other collagen chains so it doesn't get too big
- BSo it can be packed into vesicles and moved out of the cell
- CBecause the final stage in the synthesis of collagen occurs outside of the cell, where the correct enzymes are found
- DBecause it has not yet formed its triple helix structure
15Which of the following promote extracellular matrix synthesis?
- ATransforming growth factor B (TGF-B)
- BPlatelet derived growth factor
- CGlucocorticoids
- DMatrix metalloproteinases
- EIncreased age
16What are matrix metalloproteinases?
- AEnzymes that can break down collagen
- BProteins that inhibit matrix synthesis
- CEnzymes that digest fibroblasts
17Why is collagenase, a metalloprotinase, important in development?
- AIt removes parts of the body that are not needed in adult life
- BIt prevents over-growth which can put strain on the skeletal system in later life
- CIt prevent extracellular oedema
- DIt initiates apoptosis
18What is the function of gelatinase (metalloprotinase)?
- ABreaks down fibrillar collagen
- BDenatures collagen and elastin
- CBreaks down type IV collagen, fibronectin and proteoglycans
19What is the function of stromelysin (metalloproteinase)?
- ABreaks down fibrillar collagen
- BDenatures collagen and elastin
- CBreaks down type IV collagen, fibronectin and proteoglycans
20What is the pathogenesis of scurvy?
- AThe co-enzyme needed for collagen synthesis is not prevent due to dietary insufficiency
- BCross-links cannot be formed between the collagen chains because there is no enzyme to hydroxylate amino acids
- CA metabolite of vitamin C is a transcription factor that promotes the transcription of collagen. When it is not present there is no transcription.
21Why can scurvy cause tooth loss?
- ABecause there is reduced collagen in the peridontal ligaments
- BBecause there is reduced collagen in the gums so they cannot hold onto the tooth as they normally would
- CBecause there is reduced collagen in the tooth causing it to degrade within the gum and fall out
22In which gene is there a mutation in the condition osteogenesis imperfecta?
- AType I collagen
- BType II collagen
- CElastin
- DType IV collagen
- EDystophin
23Which amino acid replaces glycine in collagen's primary structure in osteogenesis imperfecta?
- ACysteine
- BLysine
- CValine
- DAspargine
- EGlutamic acid
24Why doe the change in amino acid cause the symptoms of osteogenesis imperfecta?
- ABecause the collagen helix cannot form leading to bone deformities
- BBecause the collagen molecules are now water soluble
- CBecause the collagen helix now has reduced tensile strength, leading to bone and tendon deformities
- DBecause the collagen chain is terminated prematurely, causing the molecule to be small
25What is achondrogenesis?
- ALack of bone ossification due to a mutation in the gene for type II collagen
- BLack of bone ossification due to a mutation in the gene for type I collagen
- CExcessive bone ossification dues to over-expression of the type II collagen gene
26Which of the following are symptoms of ehlers-danlos syndrome?
- AHyper-mobility
- BBlood vessel rupture
- CExcessive growth
- DReduced bone ossification
- ESkin hypopigmentation
27Elastin is synthesised in a similar way to collagen. True or false?
- ATrue
- BFalse
28What are elastin fibres wrapped in?
- AFrbrillin
- BDystrophin
- CActin
- DType IV collagen
29What type of molecule is fibrillin?
- AGlycoprotein
- BGlycosaminoglycan
- CProteoglycan
- DFibrous protein
30What is the function of fibrillin?
- AFibre integrity
- BMake the fibre insoluble in water
- CIncrease flexibility of the fibre
- DIncrease compressional strength of the fibre
- EProtect the fibre from proteases
31Which of the following inhibits the elastase enzyme?
- ATGF-B
- BA1 anti-trypsin
- CFibrillin
- DGlucocorticoids
32Collagen and elastin are laid down in vessel walls in hypertensive patients. True or false?
- ATrue
- BFalse
33What happens when collagen and elastin are laid down in blood vessel walls?
- AReduced diametre
- BIncreased wall thickness
- CIncreased vessel flexibility
- DReduced risk of rupture
34In what condition is there increase degradation of elastin within the lungs?
- APulmonary hypertension
- BEmphysema
- CAsthma
- DCOPD
- EPulmonary oedema
35What is the main symptom of cutis laxa?
- AVery lax skin
- BBlood vessels that are prone to rupture
- CSkin that is prone to rupture
- DThickened skin
36Which gene is mutated in marfans syndrome?
- AFibrillin gene
- BElastin gene
- CCollagen type IV gene
- DElastase gene
37Which of the following are symptoms of Marfan's syndrome?
- AArachnodactyly
- BAortic dilation
- CArm span longer than height
- DThickened skin
- EHypomobility of joints
- FHypopigmentation of skin
Information
- Description
- Quiz on The Extracellular Matrix , created by MPusey on 18/01/2015.
- Author
- MPusey
- Language
- English
- Views
- 97
- Tags
- Rating
- No ratings yet Rate this quiz