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Cell injury adaptations self assessment

Deleted user 13 questions

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Questions in this quiz (13)

  1. 1A 50-year-old man has experienced severe chest pain for the past 4 hours. On physical examination he is afebrile, but has tachycardia. Laboratory studies and EKG confirms a diagnosis of myocardial infarction. In this setting, an irreversible injury to myocardial fibers will have occurred when which of the following cellular changes occurs?
    1. AIncreased Na in cells
    2. BReduced cellular pH
    3. CSwelling of mitochondria
    4. DNuclear karyorrhexis
    5. EBlebs on the plasma membrane
  2. 2A 35-year-old man sustain a blunt trauma to the right leg. The skin is intact. Within 2 days there is a 5 x 7 cm purple color to the site of injury. Which of the following substances has most likely accumulated at the site of injury to produce a yellow-brown color at the site of injury 2weeks later?
    1. ALipofuscin
    2. BHemosiderin
    3. CMelanin
    4. DGlycogen
    5. EBilurubin
  3. 3Which of the following disorders is an example of coagulation necrosis?
    1. ALobar pneumonia in an alcoholic
    2. BHepatic abscess in a patient with amoebiasis
    3. CArteriolitis in Polyarteritis Nodosa (PAN)
    4. DDiminished brain mass in a patient with Alzheimer’s disease
    5. ESplenic infarction in sickle cell disease
    6. FLung consolidation in Tuberculosis
  4. 4A 31-year-old primigravida has a difficult delivery of a term infant. There is loss of 1500 cc of blood. She has hypotension for 6 hours. Over the next month, her ACTH level decreases. Within the next 3 months, her adrenal glands become only about 2 grams each (normal 4 to 6 grams). This alteration of the adrenals is primarily due to which of the following cellular processes?
    1. AMetaplasia of the cortex
    2. BLipid depletion of the cortex
    3. CAtrophy of the adrenal medulla
    4. DAtrophy of the adrenal cortex
    5. EAdrenal infarction
  5. 5A 58-year-old man with a 50-pack-year history of smoking presents with a chronic cough productive of thick, white sputum. The photograph shows a histologic section of the left main stem bronchus obtained by bronchoscopy. The arrow represents which of the following cellular adaptations?Image for question 5
    1. AAtrophy
    2. BHyperplasia
    3. CMetaplasia
    4. DHypertrophy
    5. EHypoplasia
  6. 6A 62-year-old man was admitted to the hospital with severe retrosternal chest pain that radiated down the left arm. Three days later, he developed a ventricular arrhythmia and died. In the hours shortly after the patient first experienced chest pain, which of the following biochemical changes would have marked the beginning of irreversible damage to the cardiac muscle?
    1. ADecreased intracellular Ph
    2. BDecreased sodium potassium ATPase pump activity
    3. CIncreased activity of phosphofructokinase
    4. DIncreased concentration of cytosolic calcium
    5. EIncreased conversion of pyruvate to lactate
  7. 7A 28-year-old man with a history of bronchiectasis secondary to cystic fibrosis develops bacteremia secondary to the lung condition and dies. At autopsy, a single lesion was discovered within the cerebral cortex (see image). Which of the following mechanisms is responsible for the pattern of necrosis seen in this lesion?Image for question 7
    1. ARelease of hydrolytic enzymes by neutrophils causing the tissue to liquefy
    2. BDenaturation of structural enzymes and proteins
    3. CLipid release from cell walls of tuberculous mycobacteria producing acellular material
    4. DVascular acellular necrosis in immune mediated disease producing fibrinoid deposits
  8. 8A 48-year-old man with a history of chronic alcohol abuse has epigastric pain that radiates into the back. Over three days, he develops shock and respiratory problems consistent with acute respiratory distress syndrome. The photograph shows the pancreas removed at autopsy. Which of the following best describes the type of necrosis that is present in the peripancreatic fat (black arrow)?Image for question 8
    1. ACaseous necrosis
    2. BCoagulative necrosis
    3. CEnzymatic fat necrosis
    4. DFibrinoid necrosis
    5. ELiquefactive necrosis
  9. 9A 50-year-old woman with a history of unstable angina suffers an acute myocardial infarction. Thrombolytic therapy with tissue plasminogen activator (tPA) is administered to restore coronary blood flow early in the course of this myocardial infarction. In spite of this therapy, the degree of myocardial fiber injury may increase because of which of the following cellular mechanisms?
    1. ADevelopment of a second thrombus in his coronary artery
    2. BCell damage by reactive oxygen metabolites
    3. CtPA induced apoptosis
    4. DAntibody dependent cytotoxicity
    5. EHemorrhage into the infarct
  10. 10In an experiment, a tissue preparation is subjected to oxidant stress. There are increased numbers of free radicals generated within the cells. Generation of which of the following enzymes within these cells is most likely to reduce the number of free radicals?
    1. AGlutathione peroxidase
    2. BHydrogen peroxide
    3. CNADPH oxidase
    4. DMyeloperoxidase

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User has deleted their subject information Quiz on Cell injury adaptations self assessment, created by Deleted user on 05/03/2020.
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