Quiz
PHARM - Exam 1
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Questions in this quiz (21)
1These three beta blockers are
Relative Cardioselectivity: ++
Partial Agonist Activity (ISA): 0- AAtenolol (Tenormin), Bisoprolol (Zebeta), Betaxolol (Kerlone)
- BMetaprolol (Lopressor), Nadolol (Corgard), Timolol (Blocadren)
- CCarteolol (Cartol), Penbutolol (Levatol), Pindolol (Visken)
- DNadolol (Corgard), Bisoprolol (Zebeta), Betaxolol (Kerlone)
2This beta blocker has:
Relative Cardioselectivity: +
Partial Agonist Activity (ISA): 0- AMetaprolol (Lopressor)
- BPropanolol (Inderal)
- CPenbutolol (Levatol)
- DPindolol (Visken)
3These three beta blockers have zero cardioselectivity and partial agonist (ISA) activity
- ANadolol, Propanolol, Timolol
- BAcebutolol, Carteolol, Penbutolol
- CPindolol, Nadolol, Metaprolol
- DBetaxolol, Propanolol, Penbutolol
4This beta blocker has:
Relative Cardioselectivity: ++
Partial Agonist Activity (ISA): +- AAcebutolol (Sectral)
- BPenbutolol (Levatol)
- CMetaprolol (Lopressor)
- DTimolol (Blocadren)
5These beta blockers have zero cardioselectivity, but do have ISA activity:
- ACarteolol (Cartol), Penbutolol (Levatol), Pindolol (Visken)
- BPenbutolol (Levatol), Metaprolol (Lopressor), Atenolol (Tormin)
- CPindolol (Visken), Atenolol (Tormin), Acebutolol (Sectral)
- DAcebutolol (Sectral), Nadolol (Corgard), Pindolol (Visken)
6Which enzyme deficiency leads to poor metabolism of phenytoin (Dilantin), phenobarbital, omeprazole (Prilosec), citalopram, sertraline, clopidogrel, and others?
- ACYP2C19
- BCYP2D6
- CCYP1A2
- DCYP3A4
7CYP2C19 deficiency leads to poor metabolism of:
- APhenytoin (Dilantin)
- BPhenobarbital
- COmeprazole (Prilosec)
- DCitalopram
- ESertraline
- FRifampin
- GMetoprolol
- HTheophylline
- IClopidogrel
8Increased levels of this CYP450 enzyme can lead to opioid overdose:
- ACYP2D6
- BCYP2C19
- CCYP1A2
- DCYP3A4
9The following drugs are metabolized by CYP2D6 to active metabolites:
- Atramadol
- Bhydrocodone
- Coxycodone
- Dverapamil
- Esertraline
- Fbeta blockers
- Gantidepressants
- Hrifampin
10This CYP450 enzyme is induced by rifampin, a TB antibiotic. It increases levels of theophylline, causing it's serum levels to go down.
- ACYP1A2
- BCYP3A4
- CCYP2C19
- DCYP2D6
11This CYP450 enzyme is inhibited by Ritonavir (Norvir). Sometimes it is added to lopinavir (Kaltera) to boost serum levels in patients with HIV.
- ACYP3A4
- BCYP2C19
- CCYP2D6
- DCYP1A2
12This CYP450 enzyme metabolizes Simvastatin:
- ACYP3A4
- BCYP2C19
- CCYP2D6
- DCYP1A2
13This CYP450 enzyme is decreased within 24 hrs. by administration of rifampin, and decreased up to 1 week with phenobarbital administration. It also metabolizes carbamazepine, a potent enzyme inducer:
- ACYP2C9
- BCYP1A2
- CCYP2D6
- DCYP3A4
14Resistant hypertension is failure to achieve desired blood pressure after using [blank_start]3[blank_end] different drugs from [blank_start]3[blank_end] different classes
- A3
- B3
15Target organ damage from high blood pressure can affect the following systems:
- Acardiac system
- Bcerebrovascular system
- Cperipheral vascular system
- Drenal system
- Eretinopathy
- Fcentral nervous system
- Ghepatic system
16Organs affected by neurotransmitters are known as [blank_start]effector organs[blank_end].
- Aeffector organs
17These Alpha receptors are located on postsynaptic nerve endings: [blank_start]a1[blank_end]
- Aa1
18a1 receptors function to:
- Aconstrict smooth muscle
- Bincrease peripheral vascular resistance
- Cincrease BP
- Dincrease bladder sphincter pressure
- Eincrease HR
- Fincrease myocardial contractility
19These Alpha receptors are located on presynaptic nerve endings and pancreas beta cells and allow for feedback inhibiton of norepinephrine: [blank_start]a2[blank_end]
- Aa2
20b1 receptors are located in heart muscle and function to:
- Aincrease HR
- Blipolysis
- Cincrease myocardial contractility
- Dconstrict smooth muscle
- Eincrease BP
- Fincrease bladder sphincter pressure
21b2 receptors are located in lung, periphery, and uterus and function to:
- Avasodilate
- Bbronchodilate
- Crelax uterine smooth muscle
- Dconstrict smooth muscle
- Eincrease BP
- Fincrease HR
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- Selectivity of beta blockers
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