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Cancer 3

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cell cycle questions
ivenkat
Quiz by ivenkat, updated more than 1 year ago
ivenkat
Created by ivenkat almost 9 years ago
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Resource summary

Question 1

Question
All of the following are the subphases of interphase except?
Answer
  • G1 phase
  • S Phase
  • G2 phase
  • M phase

Question 2

Question
A restriction point is when
Answer
  • a cell is irreversibly committed to cell cycle progression or apoptosis
  • a cell is reversibly committed to cell cycle progression or apoptosis
  • None of the above

Question 3

Question
Cell cycle is regulated by Cyclin-dependent kinases true or false
Answer
  • True
  • False

Question 4

Question
All of the following about Cdks are true except
Answer
  • Cdk levels are usually constant
  • Cdks are inactive in the absence of Cyclin
  • Cdks are activated by binding to Cyclins
  • Cdks phosphorylate cell regulatory proteins
  • Cdk levels vary with cell cycle

Question 5

Question
All of the following are true about Cyclin D except?
Answer
  • It is made at the start of G1 by growth factor mediated gene transcription
  • Cyclin D binds and activates CDK4,6
  • Cyclin D is degraded at the end of G1
  • Cdk 4/6 is active in the absence of cyclin D

Question 6

Question
all of the following are true except?
Answer
  • Cyclin D-CDK 4/6 will phosphorylate Rb
  • Activated Rb will release E2F
  • E2F will cause Cyclin E synthesis
  • Cyclin E binds and activates CDK-2
  • Dephosphylated Rb is active

Question 7

Question
DNA damage-induced pathways target degradation of Cyclin D first and then Cyclin E which stops cell cycle progression true or false
Answer
  • True
  • False

Question 8

Question
hypophosphorylated Rb prevents E2F activity thereby preventing cell cycle progression true or false
Answer
  • True
  • False

Question 9

Question
All of the following about negative regulators of cell cycle are correct except?
Answer
  • INK4 (inhibitors of kinase4) family bind and inhibit only cyclin D-Cdk4/6 complexes at restriction point p15,p16
  • CIP (Cdk inhibitory protein) family bind and inhibit all cyclin-Cdk complexes at the restriction point p21
  • p16 normally inhibits Cdk4
  • in the absence of p16 Cdk 4 is active and phosphorylate Rb wichin in turn activates E2F
  • p16 normally activates Cdk4

Question 10

Question
Normally p53 levels are kept low by MDM2 true or false
Answer
  • True
  • False

Question 11

Question
All of the following about p53 are correct except?
Answer
  • p53 expressed at very high levels normally
  • DNA damage leads to phosphorylation of p53 stabilizing it and increasing its concentration
  • p53 acts as transcriptional activator increasing synthesis of Cdk inhibitor p21
  • p21 inhibits Cdk/ cyclin G1 and S complexes --> cell cycle arrest in G1

Question 12

Question
Abnormally high level of Myc causes systhesis of ARF which binds and inhibits MDm2 causing increase p53 which causes cell cycle arrest true or false
Answer
  • True
  • False

Question 13

Question
Cell cycle progression at check point 2 (G2-M) is regulated by phosphorylation of Cdk1-Cyclin B complex true or false
Answer
  • True
  • False

Question 14

Question
All of the following are inducers of apoptosis except?
Answer
  • Virus infected cells
  • DNA damage
  • Growth factor withdrawal
  • Ionising radiation
  • Calcium eflux
  • tumor necrosis factor

Question 15

Question
Following is the sequence of Extrinsic apoptotic pathway except?
Answer
  • Extrinsic apoptotic pathway is initiated by binding of death-inducing ligand to a death receptor (Cys-rich repeat in the extracellular domain)
  • Death receptor are FasR and TNF receptor which are integral membrane proteins with their receptor domains exposed at the surface of te cell
  • binding of the death activator (FasL and TNF-alpha) leads to activation of caspase -9
  • which in turn initiates a cascade of caspase activation leading to cell death

Question 16

Question
All of the following are pro-apoptotic genes except
Answer
  • Bcl-2
  • Bax
  • Diva
  • Bad
  • Bik, Bim

Question 17

Question
Bid links he 2 apoptotic pathways (extrinsic and intrinsic) true or false
Answer
  • True
  • False

Question 18

Question
Both pathways converge on the activation of Caspase-3,6,7 true or false
Answer
  • True
  • False

Question 19

Question
All of the following stimulate angiogenesis except
Answer
  • VEGF
  • FGF
  • EGF
  • Angiotropin
  • Angiogenin
  • Angiostatin
  • TIP Statin anywhere stops (from static)

Question 20

Question
Hypoxia --> HIF which induces VEGF which binds to RTK and dramatically decreases metastatic potential - true or false
Answer
  • True
  • False

Question 21

Question
VEGF is secreted by all of the following except?
Answer
  • Healthy tissues needing more blood
  • Hypoxic tissues
  • Tumors
  • Highly oxygenated tissues

Question 22

Question
All the following statements are true except?
Answer
  • Bevacizumab blocks VEGF
  • Sunitinib, Sorafenib block VEGFR
  • Angiostatin inhibits plasminogen fragment
  • Endostatin inhibits endothelial cell BM collagen XVIII fragment
  • Tumstatin inhibits collagen IV fragment
  • Thrombospondin inhibits Fas-R expression
  • Cefuximab inhibits EGFR
  • Herceptin (Trastuzumab) inhibits HER2

Question 23

Question
All of the following are true except?
Answer
  • Serine proteases (uPA, tPA, plasminogen) activate MMPs
  • MMPs digest ECM by digesting type IV collagenase
  • Plasminogen promotes clotthing

Question 24

Question
Tumor motility factors AMF,HGF, EGF all promote motility via Rho GTPases - true or false
Answer
  • True
  • False

Question 25

Question
Tumor arrest in a specific tissue is by chance only true or false
Answer
  • True
  • False

Question 26

Question
Breast cancer cell express CXCR4, which bind to ligand CXCL12 in the lung,liver and bone - true or false
Answer
  • True
  • False

Question 27

Question
Major limiting step of the metastasis is the hospitability of the host microenvironment true or false
Answer
  • True
  • False

Question 28

Question
The following are matched properly except
Answer
  • Topisomerase II inhibitors: Doxorubicin and Daunorubicin
  • Vinca alkaloids (Vinblastine and Vincristine) enhances polymerization of microtubles
  • Taxol(Paclitaxel) binds and stabilizes microtubles
  • Borezomib (Velcade) blocks proteasome activity which prevents IkB degradation build up of Bax and Bak which leads to apoptosis
  • Tarceva and Iressa inhibit EGFR TKi
  • Imatinib?Gleevec inhibit TKi in CML
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