Copy and Edit

Neuro Pharmacology - Seizures & Movement Disorders

Description

Quiz/Exam for KU SOP Pharmacology III Exam I
Ifeoma Okekearu
Quiz by Ifeoma Okekearu, updated more than 1 year ago
Ifeoma Okekearu
Created by Ifeoma Okekearu over 8 years ago
10
1
0

Resource summary

Question 1

Question
An abnormal, excessive or synchronous firing of populations of brain neurons. These are transient and often reversible
Answer
  • True
  • False

Question 2

Question
Seizures are a manifestation of an imbalance between the excitatory and inhibitory pathways in the brain. Which of the following statements about seizures is incorrect
Answer
  • Excitation is due to excessive firing of glutamaterigic neurons.
  • Inhibition of GABAergic neurons can be an effect therapy for the treatment of seizures.
  • Defective inhibition of excitatory firing is major cause of seizures

Question 3

Question
At what region of the brain does the corticospinal tract decussate?
Answer
  • Midbrain
  • Medulla
  • Pons
  • Brain Stem

Question 4

Question
Na+ Channel Blockers stabilize channel in their closed, resting state making the activity of the drug activity dependent
Answer
  • True
  • False

Question 5

Question
Select all of the statements that are true regarding anti-epileptic drug Phenytoin.
Answer
  • It is the first line drug for the treatment of partial seizures.
  • Phenytoin is NOT indicated for use in absence seizures.
  • It increases the recovery of voltage-gated Na+ channels from inactivation
  • A potential side effect of phenytoin is hirsutism

Question 6

Question
Select the response that is incorrect regarding anti-epileptic drugs
Answer
  • Carbamazepine is contraindicated in the case of absence seizures
  • Valproic acid is safe effective against most partial and generalized seizures inlcuding absence seizures
  • Because of it's causes an increase in liver enzymes, valproic acid is contraindicated in children < 2 years old.
  • Anti-Epileptics that block Ca2+ (L,N) channels are effective in the treatment of absence seizures

Question 7

Question
The first line treatment for infantile spasms is ACTH or prednisone
Answer
  • True
  • False

Question 8

Question
Which statements below describe the importance of the neurotransmitter dopamine?
Answer
  • Dopamine has a significant role in learning, motor control, goal-directed behavior, and the regulation of hormones.
  • Tyrosine hydroxylase converts Tyrosine to DOPA which is rapidly converted to dopamine by DOPA decarboxylase.
  • Activation of dopamine D1-like receptors inhibits adenylyl cyclase leading to a decrease in the concentration of cAMP
  • Dopamine belongs to the catecholamine family

Question 9

Question
D2 receptors play a key role in schizophrenia and extrapyramidal movement
Answer
  • True
  • False

Question 10

Question
D4 receptors are implicated in addictive behavior.
Answer
  • True
  • False

Question 11

Question
Which of the following statements about dopaminergic pathways are correct?
Answer
  • The mesolimbic pathway is associated with motivational emotional responses
  • The mesocortical ( a part of the basal ganglia motor loop) is associated with coordination of movement
  • The tuberoinfundibulnar pathway regulates the secretion of prolactin by pituitary gland and is involved in maternal behavior
  • The mesolimbic pathway is associated with pleasure, reward, and goal-directed behavior.

Question 12

Question
Dopamine [blank_start]D2-like[blank_end] receptors [blank_start]inhibit[blank_end] adenylyl cyclase leading to a [blank_start]decrease[blank_end] in the concentration of cAMP. Dopamine D1-like receptors [blank_start]activate[blank_end] adenylyl cyclase leading to an [blank_start]increase[blank_end] in the concentration of cAMP. [blank_start]D3[blank_end] receptors are implicated in addiction. [blank_start]D2[blank_end] receptors play a key role in the pathogenesis of schizophrenia and extrapyramidal symptoms. [blank_start]D1,D5[blank_end] receptors are implicated in impulse control and mania.
Answer
  • D2-like
  • cAMP
  • D1-like
  • D1,D5
  • Impulse
  • adenylyl cyclase
  • dopamine
  • inhibit
  • decrease
  • synthesize
  • hydroxylate
  • regulation
  • D2
  • D1
  • D6
  • D4
  • D3
  • D5
  • inhibitory
  • lower
  • activated
  • increase

Question 13

Question
A patient present with an EEG showing a increased activity in a small group of neurons in the left motor cortex. Which of the following statements about the presentation of this seizure is FALSE?
Answer
  • The patient would have convulsions on the left side of the body
  • The patient will remember the seizure
  • The patient will benefit from glutaminergic potentiators
  • None of the above

Question 14

Question
An epileptic patient is in your office and loses consciousness for a brief period of time (5-10 seconds). Luckily they were hooked up to an EEG machine which documented the encounter. You see a a distinctive spike-and-wave pattern. Which statement(s) below are true?
Answer
  • This patient may have symmetrical fluttering of the eye lids during the episode
  • Low Ca2+ current in the thalamus would be discovered upon further study
  • This patient is experiencing an absence seizure
  • This patient very likely was accused of daydreaming as a child.
  • All of the above

Question 15

Question
The body uses SODIUM channels to overcome the synchronous firing of neurons in GENERALIZED TONIC-CLONIC Seizures.
Answer
  • True
  • False

Question 16

Question
Which statement about infantile spasms is FALSE?
Answer
  • These can lead to permanent cognitive delay/deficit
  • They present with sudden, repetitive, myoclonic jerks
  • Fragmentary, bilateral attacks
  • Sudden "drop attacks" with some partial seziure activity

Question 17

Question
You have a 6 year old currently recurrent periods (5-10 seconds) where they appear to daze off then come back to attention. The EEG monitory shows a distinctive spike-and-wave pattern in all regions of the brain. Which drug would be the most appropriate to treat this child's condition?
Answer
  • Phenobarbital
  • Valproic Acid
  • Ethosuximide
  • Phenytoin

Question 18

Question
Which clinical manifestations of patients suffering from Parkinson's disease is FALSE?
Answer
  • Micrograhia
  • Tightness/Stiffness of Muscles
  • Tremors that decrease with deliberate movements
  • Decrease muscle tone/strength

Question 19

Question
Parkinson's Plus Syndromes
Answer
  • Present with multiple system atrophy
  • Display with marked orthostatic hypotension
  • Respond very poorly to therapy, thus have a worse prognosis than idiopathic PD
  • Patients typically have an abnormally wide gait
  • All of the above

Question 20

Question
Which statement about cholinergic drugs is FALSE?
Answer
  • The highest content of ACh in the brain is located in the striatum
  • ACH release in inhibited by dopamine
  • Cholinergic activity due to lack of dopamine is responsible to bradykinesia.
  • Anticholinergics side effects include dry mouth, blurry vision, constipation

Question 21

Question
Ballismus
Answer
  • Usually occur younger patients
  • Treatment with anti-psychotics is ineffective
  • Movement is typically contralateral
  • Can occur due to lesions of the contralateral subthalamic nucleus
  • None of the above
Show full summary Hide full summary

Want to create your own Quizzes for free with GoConqr? Learn more.

Similar

Drug absorption, distribution, metabolism and excretion
Hannah Tribe
Neuro anatomy
James Murdoch
Exam 1 Medications
tera_alise
Pharmacology
Justin Veazey
Neuro-Cognitive Disorders
SaraJaarour
Monoamine pharmacology -Antidepressant drugs - Dr. Emma Robinson
Anna mph
NCLEX REVIEW MODEL
Jamie R Pascual
General Anaesthetics Part 1 - Steve Fitzjohn
Anna mph
Transcription
Has Maj
Cognition and Dementia - Alzheimer's disease.
Anna mph
Organelles
Has Maj
Browse Library