Histamine & Histaminergic Receptors

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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 about 7 years ago
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Year 2 Flashcards on Histamine & Histaminergic Receptors, created by gina_evans0312 on 02/06/2014.

Resource summary

Question Answer
Source of Histamine Histadine
Sources of Histamine Red granules of Mast cells, or Endochromaffin cells/histaminergic neurons
No of Histaminergic receptors 4
Receptors worked on by anti-histaminics 1 & 2
Receptors found on immune cells 1, 2 & 4
H1- Location Smooth muscle of the respiratory tract & on vascular endothelial cells
H1- Role Sooth Muscle contraction, vasodilation and immune modulation
H1- Effects Breathless/wheezing & redness/itching
H2- Location Gastroparietal & heart cells
H2- Effects Inc. acid production & inc heart contraction
H3- Location Part of the CNS
H3- Role Sleep cycle & cognition
Histamine receptors are _ coupled G-protein
Net result of histamine receptor stimulation Inc Ca2+, Adenylate Cyclase and MAPK stimulation
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