531075
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
almost 12 years ago
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| Question | Answer |
| Source of Histamine | Histadine |
| Sources of Histamine | Red granules of Mast cells, or Endochromaffin cells/histaminergic neurons |
| No of Histaminergic receptors | 4 |
| Receptors worked on by anti-histaminics | 1 & 2 |
| Receptors found on immune cells | 1, 2 & 4 |
| H1- Location | Smooth muscle of the respiratory tract & on vascular endothelial cells |
| H1- Role | Sooth Muscle contraction, vasodilation and immune modulation |
| H1- Effects | Breathless/wheezing & redness/itching |
| H2- Location | Gastroparietal & heart cells |
| H2- Effects | Inc. acid production & inc heart contraction |
| H3- Location | Part of the CNS |
| H3- Role | Sleep cycle & cognition |
| Histamine receptors are _ coupled | G-protein |
| Net result of histamine receptor stimulation | Inc Ca2+, Adenylate Cyclase and MAPK stimulation |
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