Drug discovery

Description

drug discovery questions
Sam Watkins
Quiz by Sam Watkins, updated more than 1 year ago
Sam Watkins
Created by Sam Watkins over 6 years ago
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Resource summary

Question 1

Question
what does NCE mean?
Answer
  • New clinical entity
  • National chemical entity
  • National clinical entity
  • New chemical entity

Question 2

Question
biological drugs (also known as [blank_start]biologics[blank_end]) are [blank_start]large[blank_end] molecule drugs. They are usually [blank_start]proteins[blank_end] such as [blank_start]peptides[blank_end] or antibodies but could be a nucleic acid. When discovered they are referred to as a [blank_start]NBE[blank_end]
Answer
  • biologics
  • chemologics
  • biologists
  • large
  • small
  • under 500 daltons
  • proteins
  • carbohydrates
  • vitamins
  • peptides
  • starches
  • glucose
  • NBE
  • NBB
  • NBC
  • NBA

Question 3

Question
a blockbuster drugs earns over $10 billion a year
Answer
  • True
  • False

Question 4

Question
where DON'T novel small molecules come from
Answer
  • Nature
  • Endogenous compounds
  • In silico drug design
  • you too drugs

Question 5

Question
which of the following is NOT a reason why analogue synthesis is required for endogenous lead compounds?
Answer
  • natural ligand may have undesirable duration of action
  • natural ligand may be metabolised too quickly
  • natural ligand may be chemically unstable
  • natural ligand may not have pharmacophore

Question 6

Question
synthetic drugs can be designed with computer modelling software
Answer
  • True
  • False

Question 7

Question
a me too drug has a similar structure to an existing drug, modified enough to make the compound [blank_start]novel[blank_end], but not so much that [blank_start]activity[blank_end] is affected.
Answer
  • novel
  • similar
  • typical
  • normal
  • activity
  • functional groups
  • side effects

Question 8

Question
which one of the following is true
Answer
  • side effects caused by drugs are never useful
  • side effects from drugs can be useful by providing a new lead compound for the same condition
  • side effects from drugs can be useful by providing a new lead compound for a different condition
  • side effects from drugs are always useful even if no new lead compounds are found

Question 9

Question
The definition for a lead compound is - a novel compound discovered to have pharmaceutical potential which is a good starting point for drug development.
Answer
  • True
  • False

Question 10

Question
natural product derivatives are a natural derivative of a synthetic molecule
Answer
  • True
  • False

Question 11

Question
Natural product derivatives are used as drug compounds because they are [blank_start]less[blank_end] complex and [blank_start]smaller[blank_end] so easier to deliver, and possibly [blank_start]easier to deliver[blank_end]. The active part of the molecule may be used to save [blank_start]time and money[blank_end].
Answer
  • less
  • more
  • equally as
  • smaller
  • larger
  • have a higher LogP
  • easier to deliver
  • more lipinski like
  • better formulated as creams
  • time and money
  • space
  • wastage and filtration

Question 12

Question
Which of the following are challenges with natural products
Answer
  • chrial centres which leads to 10,000's of isomers
  • unusual functional groups causes complex chemistry
  • difficult and ineffective multistep synthesis
  • novel structures means scientists cannot predict LogP values

Question 13

Question
The large molecular weight of many natural products causes:
Answer
  • I.V to often be the route of administration
  • Good absorption through SGLT channels in the duodenal epithelium
  • them to be stable in the stomach due to oxygen (ether) groups
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