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MNE First Week Practice Quiz

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Practice questions for the first week of MNE
Jim Shimoda
Quiz by Jim Shimoda, updated more than 1 year ago
Jim Shimoda
Created by Jim Shimoda over 7 years ago
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Resource summary

Question 1

Question
Congenital adrenal hyperplasia can be caused by...
Answer
  • A lack of 21-Beta-Hydroxylase
  • A lack of 11-alpha-hydroxylase
  • A lack of both
  • A lack of either
  • None of the above

Question 2

Question
A lack of oxytocin can be caused by
Answer
  • A problem with the anterior pituitary gland
  • A problem with the supraoptic nucleus of the hypothalamus
  • An excess of vasopressin
  • Grave's disease

Question 3

Question
Oxytocin and vasopressin are protected from degradation by
Answer
  • Antigens
  • Their large size
  • Amidation
  • Disulfide bridges
  • Both amidation and disulfide bridges
  • Amidation and antigens

Question 4

Question
A patient presents with moon facies, abdominal striations, a hump behind the neck, and abdominal adipose tissue build up, tests demonstrate high cortisol and high ACTH levels. This patient most likely has:
Answer
  • Addison's disease
  • Cushing's Syndrome caused by adrenal malfunction
  • Cushing's Syndrome caused by Cushing's disease
  • Wollf-Chaikov disease

Question 5

Question
Which of these is the strongest inhibitor of ACTH production?
Answer
  • High cortisol levels
  • Sleep-wake transition
  • High Growth Hormone levels
  • Hyperthyroidism

Question 6

Question
A lack of Tyrosine in the thyroid would cause
Answer
  • The overproduction of T4
  • The underproduction of T3
  • The overproduction of TBG
  • The underproduction of both T3 and T4
  • The underproduction of both TBG and TSH

Question 7

Question
Competitive inhibition of the follicular iodide pump due to excess _____________ can halt the production of ___________
Answer
  • perchlorate ; thyroid hormones
  • thyroid hormones ; TSH
  • TSH ; thyroid hormones
  • Oxytocin ; Vasopressin

Question 8

Question
(Choose the most accurate answer) - Synthesis of Thyroid hormones (T3 and T4) occurs....
Answer
  • In the pituitary gland
  • In the thyroid
  • In the follicular space
  • In the follicular cells

Question 9

Question
A patient in the first trimester of pregnancy presents with hyperthyroidism, high Thyroid hormone levels, and low TSH levels. The recommended course of treatment is
Answer
  • PTU
  • Methimazole
  • Exogenous TSH
  • Radioactive Iodine

Question 10

Question
Prenatal iodine deficiency causes
Answer
  • Cretinism
  • Overproduction of Growth Hormone
  • Grave's disease
  • Hashimoto's Thyroiditis

Question 11

Question
________ has a longer half-life in plasma
Answer
  • T4
  • T3

Question 12

Question
Conversion of T4 to T3 occurs in the:
Answer
  • Thyroid
  • Pituitary gland
  • Peripheral tissues
  • TBG

Question 13

Question
Choose the correct relationship between somatostatin and the hormone(s) below:
Answer
  • Somatostatin inhibits TSH, Promotes GH
  • Somatostatin inhibits both TSH and GH
  • Somatostatin inhibits GH, has no effect on TSH
  • Somatostatin promotes TSH and inhibits GH
  • Somatostatin has no effect on TSH or GH

Question 14

Question
Thyroid hormone receptors are:
Answer
  • Bound to DNA and activated when T3 binds to the receptor
  • In the nucleus, are activated and bind to DNA when T3 binds the receptor
  • On the membrane of cells, act via second messengers
  • Deactivated by HSP90 binding, which is only removed when T3 binds the receptor
  • Only activated by T4, not T3

Question 15

Question
Hashimoto's thyroiditis is causes
Answer
  • Hyperthyroidism
  • Hypothyroidism

Question 16

Question
Cerebral osmoreceptors in the __________ respond to changes in the blood osmolality
Answer
  • Supraoptic nucleus
  • OVLT and SFO
  • Posterior pituitary
  • Anterior pituitary

Question 17

Question
Plasma concentration of AVP is a function of....
Answer
  • ADH concentration
  • Osmotic threshold
  • Oxytocin concentration
  • Urine osmolality and Osmotic Threshold
  • Plasma osmolality and Osmotic Threshold
  • Plasma Osmolality, osmotic threshold, and BP

Question 18

Question
Maximum antidiuresis occurs at what concentration of AVP?
Answer
  • 5 pg/ml
  • 20 pg/ml
  • 5 mg/ml

Question 19

Question
At constant plasma osmolality, a decrease in blood pressure leads to
Answer
  • An increase of AVP concentration
  • An increase of oxytocin concentration
  • A decrease of AVP concentration
  • Both A and B

Question 20

Question
AVP functions by
Answer
  • Increasing the number of Aquaporins in the kidney tubule lumen
  • increasing Protein Kinase A activity in kidney tubule cells
  • Exocytosis of AQP2 containing vesicles in kidney tubule cells
  • All of the above

Question 21

Question
Nephrogenic diabetes insipidus is caused by:
Answer
  • Lack of AVP production in the posterior pituitary
  • Problems with V1a receptors in the CNS
  • Problems with V2 receptors in the kidneys
  • Problems with oxytocin receptors
  • Placental secretion of vasopressinase

Question 22

Question
If excess Potassium is detected, ____________ secretion will occur
Answer
  • Aldosterone
  • Cortisol
  • Growth Hormone
  • Vasopressin

Question 23

Question
Steroid receptors work by
Answer
  • Binding HSP90 and beginning transcription
  • Binding G-proteins that have been released by membrane receptors
  • Releasing HSP90 upon binding a steroid

Question 24

Question
What is the major dimerization partner for receptors?
Answer
  • RAR
  • RXR
  • PPAR
  • GR

Question 25

Question
In a Stachard plot, a hormone that binds two different receptors with different affinities makes a _________ line.
Answer
  • Straight
  • Curved
  • It actually makes two lines
  • Vetical
  • Horizontal

Question 26

Question
On a hormone binding curve, a left-shift equals a(n) ___________
Answer
  • Increase in affinity
  • Decrease in affinity
  • increase in plasma hormone concentration
  • Decrease in plasma hormone concentration

Question 27

Question
In the islet of Langerhans
Answer
  • Beta cells produce glucagon
  • Gamma cells produce insulin
  • Blood flows from the periphery to the center
  • Beta cells are the most numerous

Question 28

Question
In the pancreas, endocrine glands secret ___________ and exocrine glands secrete ___________
Answer
  • directly into an artery ; directly into a vein
  • into a vein ; into the digestive system
  • into the pancreatic duct ; into the venous system
  • into the digestive system ; into the liver

Question 29

Question
The cell type(s) of the islet of langerhans that serete Ghrelin are:
Answer
  • Epsilon and alpha
  • Beta and alpha
  • F cells
  • Beta only
  • epsilon only

Question 30

Question
Pancreatic F cells release:
Answer
  • Insulin
  • Glucagon
  • Somatostatin
  • Pancreatic polypeptide

Question 31

Question
Put these steps into the proper order for Insulin excretion 1) Rise in ATP 2) Opening of inflowing calcium channels 3) Entry of Glucose through the GLUT2 channel 4)Opening of Voltage gated K channel 5) Insulin secretion
Answer
  • 1, 5, 3, 4, 2
  • 3, 1, 5, 2, 4
  • 4, 3, 1, 2, 5
  • 3, 1, 4, 2, 5

Question 32

Question
Insulin exocytosis from Beta cells is most similar to which process:
Answer
  • TBG exocytosis from the thyroid follicle cells
  • Exocrine gland function of pancreas cells
  • Acetylcholine exocytosis in the Neuromuscular junction
  • Posterior pituitary hormone release

Question 33

Question
In the presence of high norepinephrine levels, the exocytosis of insulin from Beta cells is
Answer
  • Increased
  • Inhibited
  • Unaffected
  • Only affected if epinephrine is also present

Question 34

Question
How does amylin assist in glycemic regulation
Answer
  • It doesn't
  • Slows gastric emptying
  • Boosts insulin levels
  • Forms plaques that speed glucose uptake

Question 35

Question
How does caffeine effect Beta cell exhaustion
Answer
  • Dude, caffeine is bad for you. Everyone knows that.
  • Breaks up amyloid plaques, keeping Beta cells functional longer
  • Slows insulin release, regulating Beta cell function
  • Stimulates insulin release, helping relieve type 2 diabetes
  • Stimulates insulin release, helping relieve type 1 diabetes

Question 36

Question
Over-release of growth hormone in childhood causes:
Answer
  • Gigantism
  • Acromegaly
  • TSH release
  • Glucocorticoid release
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