Quiz
Immunology 6
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Questions in this quiz (37)
1Complement proteins are found in serum and tissue fluid in their...
- AActive forms
- BInactive forms
- CInactive forms in tissue fluid but active in serum
- DInactive forms in serum but active in tissue fluid
2Small serum proteins which react with foreign bodies - [blank_start]C3B[blank_end]
Large serum proteins which help destroy invading microbes - [blank_start]membrane attack complex[blank_end]
Cell surface proteins which bind products of complement activation - [blank_start]complement receptors[blank_end]- AC3B
- Bmembrane attack complex
- Ccomplement receptors
3What are the three main effector functions of complement?
- AFormation of membrane attack complex to lyse bacteria
- BOpsonisation of bacteria
- CRecruitment of phagocytes and promotion of inflammation
- DCytotoxic T cell production
- EFas/FasL binding
4The alternative complement pathway is activated by pre-existing C3b or by [blank_start]spontaneous hydrolysis[blank_end] of C3 into C3(H2O)
- Aspontaneous hydrolysis
5C3b pre-existing from the classical/lectin pathway or C3(H2O) produced by [blank_start]spontaneous hydrolysis[blank_end] leads to production of a C3 convertase [blank_start]C3bBb[blank_end] or C3(H2O)Bb. This occurs as Factor B binds to C3b or C3(H2O) and is cleaved by [blank_start]Factor D[blank_end] (a serine protease) into Bb and Ba. The formation of these C3 convertases leads to further cleaving of C3 into C3a and C3b (C3a is an [blank_start]anaphylatoxin[blank_end]). This perpetuates the reaction.
- Aspontaneous hydrolysis
- BC3bBb
- CFactor D
- Danaphylatoxin
6Collectins such as mannose binding lectin and ficolins such as L/M/H ficolin are...
- APattern recognition receptors
- BComplement receptors
- CNOD-like receptors
7Which are anaphylatoxins?
- AC3a
- BC4a
- CC5a
- DC2a
- EBa
8Mannose binding lectin contains what type of domains?
- ACarbohydrate recognition
- BFibronectin
- CCollectin
9Ficolins contain what type of domains?
- AFibronectin
- BFicolin
- CCarbohydrate recognition
10Ficolins bind oligosaccharides containing....
- AAcetylated sugars
- BMannose residues
- CFucose residues
11MBL binds to...
- AAcetylated sugars
- BMannose residues
- CFucose residues
12What initiating serine protease is associated with the lectin pathway?
- AMBL associated serine protease (MASP)
- BC1R
- CFactor D
13In the lectin pathway bound MBL or ficolin bind to [blank_start]PAMPs[blank_end] which are found on bacterial surfaces. These structures have [blank_start]MASP[blank_end] associated with them and this cleaves C4 into C4a and C4b. C4b binds C2 which is cleaved by [blank_start]MASP[blank_end] to C2a and C2b. This forms the C4bC2a [blank_start]C3 convertase[blank_end]. This can cleave many molecules of C3 to C3b and C3a. The C3b can bond [blank_start]covalently[blank_end] to the surface of the pathogen or to the C4b2a complex forming a [blank_start]C5 convertase[blank_end].
- AMASP
- BPAMPs
- CMASP
- DC3 convertase
- Ecovalently
- FC5 convertase
14C1Q binds to antibodies only.
- ATrue
- BFalse
15Opsonisation is completed by...
- AC3b only
- BC4b and C3b
- CC4b only
- DBa after cleaving by Factor D
16Which protein is the initiator of formation of the MAC?
- AC5b
- BC2b
- CProperdin
- DBa
17When only C3b is bound to bacteria, they are not phagocytosed. If an anaphylatoxin like C5a binds to macrophages on their CR1 receptor this causes phagocytosis.
- ATrue
- BFalse
18The C5 convertase of the alternative pathway is...
- AC3b2Bb
- BC4bC2aC3b
- CC3bBb
19Complement receptors tend to be found on..
- APhagocytes
- BNeutrophils
- CMacrophages
20Binding of C3b stimulates phagocytosis.
- ATrue
- BFalse
21The initiating serine protease of the classical complement pathway is...
- AC1r
- BC1s
- CC1q
22What is the correct order of activity for the anaphylatoxins?
- AC5a > C3a > C4a
- BC5a > C4a > C3a
- CC4a > C3a > C5a
- DC3a > C4a > C5a
23Which of these are functions of anaphylatoxins?
- AIncreased vascular permeability
- BIncreased binding of phagocytes to endothelial cells
- CMast cell histamine release (C5a only)
- DOpsonisation
- ELysis of cells
24C5a and C3a bind to endothelial cells to perform what function?
- AIncrease adhesion molecule production
- BOpsonisation
- CPhagocytosis
25C5a interacts with neutrophils and monocytes directly. What does it do?
- AIncrease adherence to vessel walls
- BDestroys these cells to prolong the immune response
- CCause them to become hyperactive
26The binding of C7 to C5bC6 leads to a conformational change in the constituent molecules leading to exposure of a [blank_start]hydrophobic site[blank_end] on C7 which can insert into the [blank_start]lipid[blank_end] bilayer. This occurs for C8 and C9 as well, allowing them to insert into the [blank_start]lipid[blank_end] bilayer. C8 induces the [blank_start]polymerisation[blank_end] of C9 into the [blank_start]membrane attack complex[blank_end]. This causes loss of [blank_start]proton gradient[blank_end] across the membrane and eventual destruction.
- Ahydrophobic site
- Blipid
- Clipid
- Dpolymerisation
- Emembrane attack complex
- Fproton gradient
27C8 is a complex of...
- AC8-beta
- BC8-alpha-gamma
- CC8-alpha
- DC8-gamma
28Which part of C8 induces the polymerisation of C9
- AC8-alpha-gamma
- BC8-beta
- CC8-alpha
- DC8-gamma
29Which part of C8 binds to C5b
- AC8-beta
- BC8-alpha-gamma
- CC8-alpha
- DC8-gamma
30Which part of C8 inserts into the bilayer
- AC8-alpha-gamma
- BC8-beta
- CC8-alpha
- DC8-gamma
31C1 INH disrupts...
- AC1Q complex
- BFactor D
- CProperdin
- DMASP complex
32CD59 prevents
- AFinal polymerisation of C9 molecules to form the membrane attack complex
- BC1Q complex formation
- CBinding of C3b to C4bC2a to form C5 convertase
- DSpontaneous hydrolysis of C3 into C3(H2O)
33Factor I is a..
- ASerine protease that cleaves C3b and C4b
- BCysteine protein inhibitor that cleaves C5b preventing MAC formation
- CSerine protease that cleaves Factor B into Ba and Bb
34Delay accelerating factor performs what function?
- ADisplace Bb from C3b and C2a from C4b, preventing C3 convertase formation
- BCleave C3b and C4b, preventing opsonisation
- CPrevent C9 polymerisation of the MAC
35What are homologs of host proteins?
- AFor example HVSCD59 which imitates CD59 preventing MAC formation
- BAn enzyme which cleaves host complement proteins
- CProteins different to host proteins
36Streptococci can produce a thick carbohydrate capsule which allows C3b binding but prevents [blank_start]phagocyte[blank_end] access. They can also produce proteins like Sda1 which break down [blank_start]NETS[blank_end]. They can also produce streptolysin O to cause phagocyte [blank_start]apoptosis[blank_end]. Strep can also produce SpyCEP which breaks down [blank_start]IL-8[blank_end] therefore reducing neutrophil chemotaxis.
- Aphagocyte
- BNETS
- Capoptosis
- DIL-8
37Viruses can...
- ADisrupt the C1Q complex
- BDisrupt C3 convertase
- CDisrupt C5 convertase
- DDisrupt MAC formation
Information
- Description
- Dental immunology Quiz on Immunology 6, created by 0 9 on 02/11/2016.
- Author
- 0 9
- Language
- English
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- History
- Created on 2 Nov 2016 · updated on 3 Nov 2016
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