Quiz
HUBS terms test 2
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Questions in this quiz (37)
1Action Potential steps:
1.[blank_start]Stimulus-gated Na+[blank_end] channels open
2. Membrane potential [blank_start]depolarises[blank_end]
Membrane potential reaches [blank_start]-59mV[blank_end]
3. [blank_start]Voltage-gated[blank_end] Na+ channels open
Membrane potential reaches [blank_start]+30mV[blank_end]4. Na+ channels [blank_start]close[blank_end], [blank_start]K+ channels open[blank_end]
5. Membrane potential [blank_start]repolarises[blank_end]
7. Membrane is [blank_start]hyperpolarised[blank_end]
8. [blank_start]Na+/K+ ATPase[blank_end] restores [blank_start]resting membrane potential[blank_end]- AStimulus-gated Na+
- BVoltage-gated Na+
- CK+
- Dhyperpolarises
- Edepolarises
- FVoltage-gated
- GStimulus-gated
- H-59mV
- I+59mV
- J-70mV
- K-30mV
- L+30mV
- M+39mV
- Nclose
- Oopen
- PK+ channels open
- QCl- channels open
- RCa2+ channels open
- Srepolarises
- Tstabilises
- Uresting
- Vhyperpolarised
- WNa+/K+ ATPase
- XCl- channels
- YCa2+ channels
- Zdepolarisation
- AAequal Na+ and K+ concentration
- ABResting membrane potential
2Chemical Synapse steps:
1. Pre-synaptic knob is [blank_start]depolarised[blank_end]
2. [blank_start]Voltage-gated Ca2+[blank_end] channels open
3. Triggers [blank_start]fusion of vesicles[blank_end] and pre-synaptic membrane
4. Neurotransmitter released, [blank_start]diffuses to post-synaptic membrane[blank_end]
5. Neurotransmitter binds to [blank_start]stimulus gated Na+ channels[blank_end]
6. [blank_start]Na+[blank_end] enters cell, [blank_start]depolarisation[blank_end]
note: if neurotransmitter binds to [blank_start]Cl-/K+ channels[blank_end], [blank_start]hyperpolarisation[blank_end]- Adepolarised
- Brepolarised
- CVoltage-gated Ca2+
- DStimuls-gated Ca2+
- EVoltage-gated Na+
- Ffusion of vesicles
- Grepolarisation
- Hrelease of neurotransmitter
- Idiffuses to post-synaptic membrane
- Jdiffuses to pre-synaptic membrane
- Kstimulus gated Na+ channels
- Lvoltage-gated Na+ channels
- Mstimulus -gated Ca2+ channels
- NNa+
- OCa2+
- Pdepolarisation
- QCl-/K+ channels
- Rhyperpolarisation
3Muscle contraction
1. [blank_start]ACh[blank_end] release in synaptic cleft
2. [blank_start]Action potential[blank_end] in muscle fibre
3. Action potential in [blank_start]sarcolemma[blank_end] and [blank_start]t-tubules[blank_end] triggers [blank_start]Ca2+[blank_end] release from adjacent [blank_start]sarcoplasmic reticulum[blank_end]
4. [blank_start]Ca2+ binds to troponin[blank_end]
5. Actin and [blank_start]myosin (active with ATP bound)[blank_end] bind
6. myosin head pulls actin, [blank_start]powerstroke[blank_end]
7. Ca2+ [blank_start]reuptake[blank_end] into sarcoplasmic reticulum
8. [blank_start]crosbridge uncouples[blank_end]
9. [blank_start]ATP[blank_end] binds to myosin
10. actin and myosin [blank_start]uncouple[blank_end]- AACh
- BNE
- CAction potential
- Drepolarisation
- Esarcolemma
- Ft-tubules
- Gsarcoplasmic reticulum
- HCa2+
- INa+
- JCl-
- KK+
- LCa2+ binds to troponin
- MCa2+ binds to tropomyosin
- NCa2+ binds to actin
- Omyosin (active with ATP bound)
- Pmyosin (inactive with ATP bound)
- Qmyosin
- Rpowerstroke
- Sreuptake
- Tcrosbridge uncouples
- Ucreation of crossbridge
- VATP
- Wuncouple
- Xcouple
4Smooth muscle contraction:
1. Action potential or hormones cause [blank_start]Ca2+ increase[blank_end]
2. Ca2+ binds to [blank_start]calmodulin[blank_end]
3. Calcium-calmodulin complex activates [blank_start]Myosin Light Chain Kinase[blank_end]
4. MLCK activates [blank_start]Myosin Light Chain[blank_end]
5. MLC activates [blank_start]crossbridge[blank_end]
6. [blank_start]Phosphatase inactivates[blank_end] MLCK
7. MLC [blank_start]dephosphorylated[blank_end]- ACa2+ increase
- BCa2+ decrease
- CNa+ increase
- DNa+ decrease
- Ecalmodulin
- FMyosin Light Chain Kinase
- GMyosin Light Chain
- Hcrossbridge
- IPhosphatase inactivates
- JPhosphatase reactivates
- Kdephosphorylated
- Lphosphorylated
5Peptide hormone/catecholamine second messenger signalling steps:
1. hormone binds to receptor in [blank_start]cell membrane[blank_end]
2. [blank_start]G-associated protein[blank_end] activates [blank_start]adenyl cyclase[blank_end]
3. adenyl cyclase converts ATP to [blank_start]cyclic AMP[blank_end]
4. cAMP activates [blank_start]protein kinase[blank_end]
5. kinase activates [blank_start]specific enzyme[blank_end]
6. conversion of [blank_start]substrate to product[blank_end]- Acell membrane
- Bcytoplasm
- Cnucleus
- DG-associated protein
- Eadenyl cyclase
- FA-associated protein
- Gcyclic AMP
- Hprotein kinase
- Ispecific enzyme
- Jsubstrate
- Ksubstrate to product
- Lproduct to substrate
- MDNA to RNA
- NRNA to protein
6Insulin negative feedback loop
1. [blank_start]Increased[blank_end] blood glucose
2. [blank_start]Pancreatic islet beta cells[blank_end] secrete insulin into bloodstream
3. [blank_start]Liver cells[blank_end] [blank_start]stop[blank_end] glucose output
4. Glucose uptake [blank_start]increases[blank_end] in muscle and adipose cells leading to [blank_start]increased glycogen and fat synthesis[blank_end]
5. [blank_start]Decreased[blank_end] blood glucose (back to normal)- AIncreased
- BPancreatic islet beta cells
- CPancreatic islet alpha cells
- DLiver cells
- EPancreas cells
- Fstop
- Gincrease
- Hincreases
- Idecreases
- Jincreased glycogen and fat synthesis
- Kincreased glucose and protein synthesis
- LDecreased
7Glucagon negative feedback loop:
1. [blank_start]Decreased[blank_end] blood glucose
2. [blank_start]Pancreatic islet alpha cells[blank_end] secrete glucagon into bloodstream
3. [blank_start]Liver cells[blank_end] increase [blank_start]glycogen[blank_end] breakdown, [blank_start]glucose[blank_end] synthesis and [blank_start]ketone[blank_end] synthesis
4. [blank_start]Increased[blank_end] blood glucose [blank_start](and blood ketone)[blank_end]- ADecreased
- BPancreatic islet alpha cells
- CPancreatic beta cells
- DLiver cells
- Eglycogen
- Fglucose
- Gketone
- HIncreased
- I(and blood ketone)
- J(and blood glycogen)
8Growth hormone negative feedback loop:
1. Hypothalamus stimulates [blank_start]growth hormone releasing hormone neuron[blank_end]
2. Releases GHRH
3. Stimulates [blank_start]anterior pituitary gland[blank_end] to [blank_start]release[blank_end] growth hormone
4. [blank_start]Increases[blank_end] triglyceride breakdown and fat cell [blank_start]glucose uptake[blank_end], [blank_start]increases[blank_end] protein synthesis
5. Stimulates liver to release [blank_start]insulin-like growth factor 1[blank_end] and increase [blank_start]glucose synthesis[blank_end]
6. IGF-1 promotes [blank_start]growth[blank_end] of bones, muscle, other tissue
7. IGF-1 [blank_start]inhibits[blank_end] GHRH neurons, [blank_start]stimulates[blank_end] somatostatin neurons
8. SS neurons release SS
9. SS [blank_start]inhibits release of GH[blank_end] from anterior pituitary gland- Agrowth hormone releasing hormone neuron
- Banterior pituitary gland
- Crelease
- Dstore
- EIncreases
- FDecreases
- Gglucose uptake
- Hglucose release
- Iincreases
- Jinsulin-like growth factor 1
- Kglucose synthesis
- Lglucose storage
- Mgrowth
- Nbreakdown
- Oinhibits
- Pstimulates
- Qinhibits release of GH
- Rstimulates release of GH
9Cortisol negative feedback loop:
1. [blank_start]Stress[blank_end] or [blank_start]decreased[blank_end] blood glucose stimulates [blank_start]hypothalamus[blank_end]
2. Secretes [blank_start]cortisol releasing hormone[blank_end]
3. [blank_start]anterior pituitary[blank_end] secretes [blank_start]adrenocorticotrophic hormone[blank_end]
4. [blank_start]adrenal cortex[blank_end] secretes cortisol
5. [blank_start]Increases[blank_end] glucose [blank_start]synthesis[blank_end] in liver, decreases glucose [blank_start]uptake[blank_end] in [blank_start]muscle and fat cells[blank_end], increases protein and fat [blank_start]breakdown[blank_end] and increases [blank_start]blood pressure[blank_end]- AStress
- Bdecreased
- Cincreased
- Dcortisol releasing hormone
- Eadrenocorticotrophic hormone
- Fadrenal cortex
- Ganterior pituitary
- Hhypothalamus
- IIncreases
- JDecreases
- Ksynthesis
- Luptake
- Mmuscle and fat cells
- Nbone cells
- Oliver cells
- Pbreakdown
- Qblood pressure
- Rblood volume
10Adrenaline negative feedback loop
1. [blank_start]Stress[blank_end] or [blank_start]decreased[blank_end] blood glucose stimulates hypothalamus
2. Stimulates [blank_start]adrenal medulla[blank_end] via [blank_start]sympathetic pre-ganglionic fibres[blank_end] to secrete adrenaline
3. Increases [blank_start]glucogenesis[blank_end] in [blank_start]liver and skeletal muscle[blank_end], increases [blank_start]heart rate[blank_end] and [blank_start]blood pressure[blank_end]- AStress
- Bdecreased
- Cincreased
- Dadrenal medulla
- Eadrenal cortex
- Fmiddle adrenal cortex
- Gsympathetic pre-ganglionic fibres
- Hparasympathetic pre-ganglionic fibres
- Iparasympathetic post-ganglionic fibres
- Jsympathetic post-ganglionic fibres
- Kglucogenesis
- Lglycogenesis
- Mglucolysis
- Nglycolysis
- Oliver and skeletal muscle
- Pheart rate
- Qblood pressure
- Rblood volume
11Anti-diuretic hormone negative feedback loop:
1. Stress or [blank_start]decreased[blank_end] blood glucose stimulates [blank_start]hypothalamus[blank_end]
2. Stimulates [blank_start]posterior pituitary[blank_end] via [blank_start]neurons[blank_end] to secrete anti-diuretic hormone
3. Acts on [blank_start]kidney[blank_end] to [blank_start]decrease[blank_end] water [blank_start]excretion[blank_end], [blank_start]increase[blank_end] [blank_start]blood volume[blank_end] and blood pressure- Adecreased
- Bincreased
- Chypothalamus
- Dposterior pituitary
- Eneurons
- Fbloodstream
- Ghormones
- Hkidney
- Iliver
- Jpancreas
- Kdecrease
- Lexcretion
- Muptake
- Nincrease
- Oblood volume
12Thyroid hormone negative feedback loop:
1. External and internal [blank_start]CNS[blank_end] input
2. [blank_start]Hypothalamus[blank_end] secretes [blank_start]thyroid releasing hormone[blank_end] into the blood
3. [blank_start]Anterior pituitary[blank_end] [blank_start]secretes thyroid stimulating hormone[blank_end] into the blood
4. [blank_start]Thyroid gland[blank_end] secretes [blank_start]thyroid hormone (T3 and T4)[blank_end] into the blood
5. [blank_start]Increases[blank_end] activity and synthesis of [blank_start]Na+/K+ pump[blank_end] which [blank_start]increases[blank_end] basal metabolic rate- ACNS
- BPNS
- Cthyroid releasing hormone
- DHypothalamus
- EAnterior pituitary
- Fsecretes thyroid stimulating hormone
- GThyroid gland
- Hthyroid hormone (T3 and T4)
- INa+/K+ pump
- JIncreases
- KDecreases
- Lincreases
- Mdecreases
13Parathyroid hormone negative feedback loop:
1. Decreased [blank_start]plasma Ca2+[blank_end] concentration
2. Stimulates [blank_start]parathyroid hormone[blank_end] release
3. Increases bone [blank_start]breakdown[blank_end], [blank_start]kidney Ca2+[blank_end] reabsorption and conversion of [blank_start]vitamin D to cacitriol[blank_end]
4. [blank_start]Calcitriol[blank_end] increases [blank_start]intestine Ca2+[blank_end] absorption- Aplasma Ca2+
- BICF Ca2+
- Cparathyroid hormone
- Dbreakdown
- Eformation
- Fkidney Ca2+
- Gvitamin D to cacitriol
- HCalcitriol
- Iintestine Ca2+
14Calcitonin negative feedback loop:
1. [blank_start]Increased[blank_end] blood Ca2+
2. Stimulates [blank_start]thyroid gland[blank_end] to secrete calcitonin
3. [blank_start]Increases[blank_end] bone [blank_start]breakdown[blank_end]- AIncreased
- BDecreased
- Cthyroid gland
- Dparathyroid gland
- EIncreases
- FDecreases
- Gbreakdown
- Hformation
15Blood pressure negative feedback loop
1. [blank_start]Decrease[blank_end] blood pressure detected by stretch receptors
2. [blank_start]Kidney cells[blank_end] release hormones into [blank_start]blood[blank_end] which act on:
- [blank_start]Adrenal glands[blank_end] release [blank_start]aldosterone[blank_end] which increases [blank_start]kidney Na+ reabsorption[blank_end]
- [blank_start]Pituitary gland[blank_end] releases [blank_start]ADH[blank_end] which increases [blank_start]water reabsorption[blank_end]
- Blood vessels [blank_start]vasoconstrict[blank_end]
- [blank_start]hypothalamus[blank_end] creates feeling of thirst- ADecrease
- BIncrease
- CKidney cells
- DLiver cells
- Eblood
- Fnervous system
- GAdrenal glands
- Haldosterone
- Ikidney Na+ reabsorption
- JPituitary gland
- KADH
- Lwater reabsorption
- Mvasoconstrict
- Nvasodilate
- Ohypothalamus
16Thyroid hormone synthesis:
1. [blank_start]Iodine[blank_end] from bloodstream reacts with the [blank_start]tyrosine[blank_end] in [blank_start]thyroglobulin[blank_end] molecules in [blank_start]follicular cells[blank_end]
2. [blank_start]T3 and T4[blank_end] detach from [blank_start]iodised TGB[blank_end] molecule in [blank_start]parafollicular cells[blank_end]- AIodine
- Btyrosine
- Cthyroglobulin
- Dfollicular cells
- ET3 and T4
- Fiodised TGB
- Gparafollicular cells
17What are the effects of glucagon?
- Aincreases glycogen breakdown
- Bdecreases glycogen breakdown
- Cincreases glucose synthesis
- Dincreases ketone synthesis
- Edecreases ketone synthesis
- Fdecreases glucose synthesis
18What are the effects of thyroid hormone?
- AIncreases BMR
- BIncreases Na+/K+ pump synthesis
- CDecreases Na+/K+ pump activity
- Dstimulates growth
- Einhibits growth
19What are the effects of adrenaline?
- ADecreases heart rate
- BDecreases blood pressure
- CIncreases blood glucose
20What are the effects of cortisol?
- AIncreased glucose synthesis
- BIncreased glucose cellular uptake
- Cdecreased protein and fat breakdown
- Ddecreased heart rate
21What are the effects of insulin?
- AIncreases glucose output
- BIncreases net glucose uptake
- CIncreases glycogen, protein and fat synthesis
22What are the effects of antidiuretic hormone?
- AIncreased water excretion
- BDecreased blood volume
- Cincreased blood volume
- Ddecreased blood pressure
- Eincreased blood pressure
23What are the effects of parathyroid hormone?
- AIncreased plasma Ca2+ concentration
- Bdecreased bone breakdown
- Cdecreased kidney Ca2+ reabsorption
- DConversion of calcitriol to vitamin D
- EIncreased intestine Ca2+ absorption
24What are the acute effects of hyperglycemia?
- AExcess sugar in urine
- Bthrist
- Cprotein and fat synthesis
- Dketoacidosis
- Eno appetite
25What are the chronic effects of hyperglycemia?
- ACardiovascular disease
- BExcessive urination
- CImproved eyesight
- DPoor wound healing
- EPeripheral nerve damage
- FDecreased susceptibility to infection
26Which of these characterise Addison's disease?
- AIncreased aldosterone
- BToo little cortisol
- CIncreased ACTH secretion
- Dincreased melanin in skin
27Cushing's syndrome is caused by a deficiency in cortisol
- ATrue
- BFalse
28Cretinism is caused by a deficiency in thyroid hormone
- ATrue
- BFalse
29What are the symptoms of Grave's disease?
- Ahyposecretion of thyroid hormone
- Bhypersecretion of cortisol
- CHigh metabolic rate
- Dheat intolerance
- Eexpothalmos
- Ftissue swelling
- Gdecreased heart rate
- HWeight gain
30>1.9mmol/L glucose causes parasthesia and laryngospasm
- ATrue
- BFalse
31>3mmol/L blood glucose causes:
- Aincreased nervous system excitability
- Bemotional disturbances
- Cweak muscles
- Dheightened reflexes
32Somatosensory pathway:
Neuron 1: [blank_start]receptor[blank_end] to [blank_start]dorsal ganglion[blank_end]
Neuron 2: differs between [blank_start]medial lemniscal[blank_end] and [blank_start]laterospinothalamic[blank_end]
Neuron 3: [blank_start]thalamus[blank_end] to [blank_start]somatosensory cortex[blank_end]- Areceptor
- Bdorsal ganglion
- Cmedial lemniscal
- Dlaterospinothalamic
- Ethalamus
- Fsomatosensory cortex
33Medial lemniscal pathway relays [blank_start]touch[blank_end] and [blank_start]proprioception[blank_end] information to the [blank_start]somatosensory cortex[blank_end]. The direction is [blank_start]up[blank_end] and [blank_start]across[blank_end]. Neuron 2 moves [blank_start]up the spinal cord[blank_end], crosses at the [blank_start]medulla[blank_end] and synapses in the [blank_start]thalamus[blank_end].
- Atouch
- Bpain
- Cproprioception
- Dtemperature
- Esomatosensory cortex
- Fmotor cortex
- Gup
- Hacross
- Imedulla
- Jup the spinal cord
- Kthalamus
34Laterospinothalamic pathway relays [blank_start]pain[blank_end] and [blank_start]temperature[blank_end] information to the somatosensory cortex. The direction is [blank_start]across[blank_end] and [blank_start]up[blank_end]. The second neuron [blank_start]crosses at the dorsal ganglion[blank_end], moves up the [blank_start]spinal cord[blank_end] and synapses at the [blank_start]thalamus[blank_end].
- Apain
- Btouch
- Ctemperature
- Dproprioception
- Eacross
- Fup
- Gcrosses at the dorsal ganglion
- Hspinal cord
- Ithalamus
35Laterospinothalamic pathway relays [blank_start]pain[blank_end] and [blank_start]temperature[blank_end] information to the somatosensory cortex. The direction is [blank_start]across[blank_end] and [blank_start]up[blank_end]. Neuron 2 crosses at the [blank_start]dorsal root ganglion[blank_end], moves up the [blank_start]spinal cord[blank_end] and synapses in the [blank_start]thalamus[blank_end].
- Apain
- Btouch
- Ctemperature
- Dproprioception
- Eacross
- Fup
- Gdorsal root ganglion
- Hspinal cord
- Ithalamus
36The corticospinal pathway relays instructions for [blank_start]precise movement of hands and feet[blank_end]. The upper motor neuron [blank_start]crosses at the medulla[blank_end]. The synapse between the upper motor neuron and the lower motor neuron is in the [blank_start]ventral horn[blank_end] and [blank_start]is always excitatory[blank_end].
- Aprecise movement of hands and feet
- Bautomatic movements we are aware of
- Ccrosses at the medulla
- Dventral horn
- Epons and medulla
- Fis always excitatory
- Gcan be excitatory or inhibitory
37The non-corticospinal pathway relays instructions for [blank_start]automatic movements we are aware of[blank_end]. The upper motor neuron [blank_start]crosses at the medulla[blank_end]. The synapse between the upper motor neuron and the lower motor neuron is in [blank_start]the midbrain and pons[blank_end] and [blank_start]can be excitatory or inhibitory[blank_end].
- Aautomatic movements we are aware of
- Bprecise movement of the hands and feet
- Ccrosses at the medulla
- Dthe midbrain and pons
- Ethe ventral horn
- Fcan be excitatory or inhibitory
- Gis excitatory
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- Quiz on HUBS terms test 2, created by Hannah Gordon on 19/05/2017.
- Author
- Hannah Gordon
- Language
- English
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