Flussdiagramm
HR explained
Inhalt des Flussdiagramms
Initiated by MRN complex (identification)
Recruits TIP60 and ATM
Activated ATM phosphorylateH2AX(scaffold for MDC1)
RNF8 and RNF168 ubiquitinates H2AX
53BPI and BRCA1 binds
Also recruits RAD51 & RPA
MRN+CtIP creates 3’ overhang
Extended by BLM and EXO1 to form nucleoprotein filament
Invades adjacent strand producing a D-loop
RTEL1 complex cleaves
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- Flussdiagramm am HR explained, erstellt von Rithika Bekal am 22/10/2021.
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- Rithika Bekal
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