Flowchart
HR explained
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Initiated by MRN complex (identification)
Recruits TIP60 and ATM
Activated ATM phosphorylateH2AX(scaffold for MDC1)
RNF8 and RNF168 ubiquitinates H2AX
53BPI and BRCA1 binds
Also recruits RAD51 & RPA
MRN+CtIP creates 3’ overhang
Extended by BLM and EXO1 to form nucleoprotein filament
Invades adjacent strand producing a D-loop
RTEL1 complex cleaves
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- Flowchart on HR explained, created by Rithika Bekal on 22/10/2021.
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- Rithika Bekal
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