Karteikarten
GTN formulations
Karten in diesem Stapel (9)
- 1Describe the design of a reservoir system transdermal GTN patch
- 2Describe the design of a matrix system transdermal GTN patch
- 3Why do we administer glyceryl trinitrate tablets (Anginine) sublingually?1. rapid absorption into systemic circulation for rapid effect
2. avoid first pass metabolism - 4How should a patient store Anginine (GTN) tablets and why?1. in original container and tightly sealed as drug is volatile and it adsorbs to plastic
2. away from body- body temperature will lead to loss of drug (volatility)
3. in a cool place (volatility and decomposition)
4. discard 3months after opening (loss of potency) - 5Why are patients instructed to apply a GTN transdermal patch at 8am and remove at 8pm?this gives patient a nitrate free period and reduces the development of tolerance to this drug
- 6Explain mechanism of action of glyceryl trinitratenitric oxide released from nitrate activates guanylate cyclase which converts GTP to cGMP and this activates cGMP-dependent protein kinase which acts to reduce intracellular calcium causing smooth muscle relaxation
- 7what is an advantage of GTN as a spray formulation? (nitrolingual spray)if patient has infrequent angina attacks, this preparation has a much longer shelf-life (2 years)
- 8What directions would you give patient on using GTN as a sprayuse SL
prime the first time used or if not used for 7 days - 9Why do we not give isosorbide mononitrate extended release tablets twice daily (every 12h)to ensure there is a nitrate free time to reduce development of tolerance
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- Beschreibung
- To assist in revising lecture on cardiovascular formulations
- Erstellt von
- jenny schneider
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- 275
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