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A N T I C O A G U L A N T S

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pharmacy Cardio Mind Map on A N T I C O A G U L A N T S, created by Kaytlynn Fisher on 03/04/2019.
Kaytlynn Fisher
Mind Map by Kaytlynn Fisher, updated more than 1 year ago
Kaytlynn Fisher
Created by Kaytlynn Fisher about 5 years ago
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A N T I C O A G U L A N T S
  1. MOA
    1. HIGH MOLECULAR WEIGHT HEPARINS
      1. SIGNIFICANT inhibition of Xa & IIa • • • MINOR inhibition of VIIa, IXa, & XIIa • • • Active clotting factors INACTIVATED • • • INDIRECT thrombin inhibitor • • • enhances effects of antithrombin III
        1. HEPARIN
        2. LOW MOLECULAR WEIGHT HEPARINS
          1. ENHANCES the effects of antithrombin III • • • SIGNIFICANT inhibition of Xa • • • Some inhibition of IIa • • • Active clotting factors INACTIVATED
            1. ENOXAPARIN • • Lovenox
              1. DALTEPARIN • • Fragmin
              2. VITAMIN K ANTAGONIST
                1. Interacts with Vit K cycle • • • Factor II, VII, IX, & X • • • INHIBITS Vit K epoxide reductase ( VKORC1 ) which converts Vit K to its activa form ( KH2 ) → → No longer a cofactor of carboxylase → → less K → Less K dependent clotting factors produced → ALSO inhibits protein C and S
                  1. WARFARIN • • Coumadin
                  2. FACTOR Xa INHIBITORS
                    1. ACUTE
                      1. FONDAPARINUX • • Atrixa
                        1. Augments function of ATII • • Significant inhibition of Xa only • • Active clotting factors inactivated (Only Xa)
                        2. CHRONIC
                          1. DOES NOT AFFECT ANTITHROMBIN • • • Directly inhibits Factor Xa by BLOCKING the active site
                            1. APIXABAN • Eliquis • • • • RIVAROXABAN • Xarelto • • • • EDOXABAN • Sayvasa • • • • BETRIXABAN • Bevyxxa
                          2. DIRECT THROMBIN INHIBITORS
                            1. DABIGATRAN • Pradaxa • • • • ARGATROBAN • • • • BIVALIRUDIN • Angiomax • • • • DESIRUDIN • Iprivask
                              1. DIRECTLY inhibits Factor IIa ( Thrombin ) by binding the active site
                              2. FIBRINOLYTICS
                                1. Breaks up clots by converting plasminogen to plasmin
                                  1. ALTEPASE • Activase / Cathflo
                                2. INDICATIONS
                                  1. MONITORING
                                    1. REQUIRED MONITORING
                                      1. HEPARIN
                                        1. APTT (ACTIVATED PARTIAL THROMBOPLASTIN TIME) • • • GOAL = 1.5 - 2.5 CONTROL RANGE
                                      2. NO REGULAR - REQUIRED MONITORING
                                      3. INTERACTIONS
                                        1. CONTRAINDICATIONS
                                          1. CONTRAINDICATED IN CRCL < 30 ML/MIN
                                            1. DABIGATRAN (- PRADAXA -)
                                              1. FONDAPARINUX (- ATRIXA -)
                                            2. AGENT - AGENT CONVERSION
                                              1. FORMULATIONS
                                                1. ORAL
                                                  1. WARFARIN
                                                    1. APIXABAN
                                                      1. RIVAROXABAN
                                                        1. EDOXABAN
                                                          1. BETRIXABAN
                                                            1. DABIGATRAN
                                                            2. S Q
                                                              1. ENOXAPARIN
                                                                1. DALTEPARIN
                                                                  1. HEPARIN - NOT COMMON
                                                                  2. IV
                                                                    1. HEPARIN
                                                                      1. FONDAPARINUX
                                                                        1. ARGATROBAN
                                                                          1. BIVALIRUDIN
                                                                            1. DESIRUDIN
                                                                              1. ATLEPASE
                                                                                1. RETEPLASE
                                                                                  1. TENECTEPLASE
                                                                                2. DRUG SPECIFIC POINTS
                                                                                  1. ADRs
                                                                                    1. COUNSELING
                                                                                      1. REVERSAL AGENTS
                                                                                        1. MEDICATION CLASS
                                                                                          1. HIGH MOLECULAR WEIGHT HEPARIN (HMWH)
                                                                                            1. UNFRACTIONATED HEPARIN (UFH)
                                                                                            2. LOW MOLECULAR WEIGHT HEPARINS
                                                                                              1. ENOXAPARIN - (LOVENOX)
                                                                                                1. DALTEPARIN - (FRAGMIN)
                                                                                                2. COURMARIN ( - VIT K - ) DERIVATIVE
                                                                                                  1. WARFARIN ( - COUMADIN - )
                                                                                                  2. FACTOR Xa INHIBITORS
                                                                                                    1. FONDAPARINUX ( - ARIXTRA - )
                                                                                                      1. APIXABAN ( - ELIQUIS - )
                                                                                                        1. RIVAROXABAN ( - XARELTO - )
                                                                                                          1. EDOXABAN ( - SAVAYSA - )
                                                                                                            1. BETRIXABAN ( - BEVYXXA - )
                                                                                                            2. DIRECT THROMBIN INHIBITORS
                                                                                                              1. DABIGATRAN ( - PRADAXA - )
                                                                                                                1. ARGATROBAN
                                                                                                                  1. BIVALIRUDIN (- ANGIOMAX -)
                                                                                                                    1. DESIRUDIN (- IPRIVASK -)
                                                                                                                    2. FIBRINOLYTICS
                                                                                                                      1. ATLEPASE (- ACTIVASE / CATHFLO -)
                                                                                                                        1. RETEPLASE (- RATEVASE -)
                                                                                                                          1. TENECTEPLASE (- TNKase -)

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