Karteikarten
PATHO LE2: Neoplasia
Karten in diesem Stapel (43)
- 1polygonal cells ecto/endodermal originCarcinoma
- 2spindle-shaped cells mesodermal originSarcoma
- 3Chronic Myelogenous Leukemia; Philadelphia Chromosometranslocation: chromosome 9 & 22
= BCR-ABL chimera - 4NeuroblastomaAmplification of N-MYC gene
(2p, double minute) - 5Burkitt's Lymphomat(8;14) = MYC protein
- 6Walker's Law50% of Px w/ newly diagnosed solid malignant neoplasms have metasteses
- 7Two-hit hypothesis: Retinoblastomaboth alleles of RB gene at 13q14
- 8common mutated genes in cancerp53, RAS, BRCA1/2
- 9protein products assist oncogene activityEGF, PDGF, CSF-1, TGF-a
- 10multiple malignancies, develop at a younger age, multiple primary tumors of varying types (syndrome? mutation?)Li-Fraumeni Syndrome
deletion of one arm of p53 - 11most common carcinogen?Radon
- 12pre-cancerous conditions in which malignancy is most likely to occurliver cirrhosis, chronic ulcerative colitis, atrophic gastritis, epidermal actinic keratosis, oral leukoplakia
- 13competitive antagonist of estrogen receptorTamoxifen
- 14cancers most seen in young adult malesTesticular, Hodgkin's
- 15cancers more frequent in older menProstate Cancer
- 16cancers most frequent in childrenleukemia, brain tumors
- 17overexpression of PDFGB (PDGF-B chain)Astrocytoma
- 18overexpression of HST1 (fibroblast growth factors)Osteosarcoma
- 19amplification of FGF3 (fibroblast growth factors)Stomach, Bladder, Breast CA, Melanoma
- 20overexpression of TGF-A (TGF-a)Astrocytoma
- 21overexpression of HGFHepatocellular carcinomas,
Thyroid cancer - 22mutation/amplification of ERBB1, ERBB2 (EGFR, HER)Adenocarcinoma of lung,
Breast carcinma - 23point mutation of FLT3 (FMS-like tyrosine kinase 3)Leukemia
- 24point mutation of RET (receptor for neurotrophic factors)Multiple endocrine neoplasia 2A and B,
Familial medullary thyroid carcinomas - 25overexpression/translocation of PDGFRB (PDGF receptor)Gliomas, Leukemias
- 26point mutation in KIT (receptor for KIT ligand)GI stromal tumors, seminomas, leukemias
- 27translocation/fusion gene formation of ALK (ALK receptor)Adenocarcinoma of lung,
certain lymphomas - 28point mutation of ALKNeuroblastoma
- 29point mutation of KRAS (G protein)Colon, Lung, Pancreatic tumors
- 30point mutation of HRAS (G protein)Bladder and Kidney tumors
- 31point mutation of NRAS (G protein)Melanomas, Hematologic malignancies
- 32point mutation of GNAQ (G protein)Uveal melanoma
- 33point mutation of GNAS (G protein)Pituitary adenoma,
other endocrine tumors - 34translocation of ABL (nonreceptor tyrosine kinase)Chronic Myelogenous Leukemia
- 35point mutation of ABL (nonreceptor tyrosine kinase)Acute Lymphoblastic Leukemia
- 36point mutation, translocation of BRAF (RAS signal transduction)Melanomas, Leukemias,
Colon carcinoma - 37point mutation, translocation, gene arrangement of NOTCH1 (Notch signal transduction)Leukemias, Lymphomas,
Breast carcinoma - 38translocation of JAK2 (JAK/STAT)Myeloproliferative disorders, ALL
- 39translocation of MYC (transcriptional activators)Burkitt Lymphoma
- 40amplification of NMYC (transcriptional activators)Neuroblastoma
- 41translocation of CCND1 (Cyclin D1)Mantle cell lymphoma,
Multiple myeloma - 42Amplification of CCND1 (cyclin D1)Breast and Esophageal cancers
- 43amplification/point mutation of CDK4 (cyclin-dependent kinase)Glioblastoma, Melanoma, Sarcoma