Karteikarten
S08.03
Karten in diesem Stapel (9)
- 1ion pairing in Hb subunitsCaused by COO- from one subunit to amino groups in other subunit
- 2Chatliers principle & HbR/HbTwhen HbR is formed/ (O2 makes it stuck in HbR form), more HbR turns to HbT to compensate
- 3Why does Hb have 10X less affinity for O2 in vivo?BPG !! greatly decreases affinity
BPG binds HbT not HbR - 4BPGallosteric (other site)
Hb binds EITHER O2 or BPG not both
4-5 - charges, side rxn. of glycolysis - 5Where does the BPG bind?ONE spot / Hb
2 Beta chain's cation groups meet in HbT
(not present in HbR) - 6HbA vs HbF (adult, fetus)HbF p50= lower so that O2 always transfers
HbF: alpha2Gamma2
HbA: alpha2Beta2
HbF: LOWER BPG affinity - 7pH affects Hb, Mb ?doesnt affect Mb, lowering pH lowers Hb O2 affinity (p50)
pKa / H+ affinity is higher for HbT - 8O2 & CO2, Hbincreased O2 --> decreased CO2 affinity, easier to dissociate
Increased CO2 --> decreased O2 affinity - 9CO effectsBinds 200X tighter than O2, dangerous
Informationen
- Beschreibung
- Karteikarten am S08.03, erstellt von Zoe Fernyhough am 12/10/2016.
- Erstellt von
- Zoe Fernyhough · Okt 2016
- Aktualisiert
- 12 Nov 2016
- Aufrufe
- 0
- Bewertung
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