Flashcards

S08.03

Zoe Fernyhough English 9 cards

Cards in this deck (9)

1ion pairing in Hb subunitsCaused by COO- from one subunit to amino groups in other subunit
2Chatliers principle & HbR/HbTwhen HbR is formed/ (O2 makes it stuck in HbR form), more HbR turns to HbT to compensate
3Why does Hb have 10X less affinity for O2 in vivo?BPG !! greatly decreases affinity
BPG binds HbT not HbR
4BPGallosteric (other site)
Hb binds EITHER O2 or BPG not both
4-5 - charges, side rxn. of glycolysis
5Where does the BPG bind?ONE spot / Hb
2 Beta chain's cation groups meet in HbT
(not present in HbR)
6HbA vs HbF (adult, fetus)HbF p50= lower so that O2 always transfers
HbF: alpha2Gamma2
HbA: alpha2Beta2
HbF: LOWER BPG affinity
7pH affects Hb, Mb ?doesnt affect Mb, lowering pH lowers Hb O2 affinity (p50)
pKa / H+ affinity is higher for HbT
8O2 & CO2, Hbincreased O2 --> decreased CO2 affinity, easier to dissociate
Increased CO2 --> decreased O2 affinity
9CO effectsBinds 200X tighter than O2, dangerous