Karteikarten
PHRM20001 Lecture 6 Adrenergics
Karten in diesem Stapel (17)
- 1What are the Catecholamines?Noradrenaline
Adrenaline
Dopamine - 2Catecholamine Synthesis: (5) Substrates (3) Enzymes
- 3CocaineBlocks catecholamine reuptake channels
Allows Noradrenaline to remain in the synapse for prolonged period - 4MAO-Inhibitors Monoamine Oxidase InhibitorsInhibits the degradation of Noradrenaline so that increased levels remain in the neuron
- 5SympathomimeticsDrugs that mimick Noradrenaline (have similar structure) and so compete to bind to MAO, displacing NA and maintaining higher levels of NA.
e.g. Amphetamine, Ephidrine, Tyramine
Isoprenaline, Phenylephrine - 6Alpha 1 ReceptorsPost junctional
Gq Protein
Causes increase in IP3 and DAG
Constriction of Vascular Smooth Muscle
Vasoconstriction - 7PhenylephrineSelective Alpha Agonist
- 8PhentolamineSelective Alpha Receptor Antagonist
- 9IsoprenalineSelective Beta Receptor Agonist
- 10PropranololSelective Beta Receptor Antagonist
- 11PrazosinSelective Alpha 2 Receptor Antagonist
(Hypertension) - 12ClonidineSelective Alpha 2 Agonist
- 13Alpha 1 Receptors (1) Location (1) G Protein (1) Associated Protein (1) 2nd Messengers (1) EffectLocated on Vascular Smooth Muscle
Gq Protein
Phospholipase C
Increase in IP3 and DAG
Causes Vasoconstriction - 14Alpha 2 Receptors (1) Location (1) G Protein (1) Associated Protein (1) 2nd Messengers (1) EffectLocated on Prejunctional Neurons
But Also Gut and GIT
Gi (Inhibitory)
Adenylate Cyclase
Decrease in cAMP
Decrease in NA release (Neg Feed) - 15Beta 1 Receptors (1) Location (1) EffectLocated on the Heart
Causes stimulation
Increase in Contractile Force and Rate - 16Beta 2 Receptors (1) Location (1) EffectLocated on the Smooth Muscle of Bronchi
Blood Vessels of Heart, Liver, Sk.Muscle
Has an inhibitory effect
Bronchodilation Vasodilation
Responds to Adrenaline - 17Beta Receptors (1) G Protein (1) Associated Protein (1) 2nd MessengersGs Protein
Adenylate Cyclase
Increase in cAMP
Either Inhibitory or Stimulatory Effect
Depending on Location, Type of Receptor
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- Beschreibung
- Pharmacology Karteikarten am PHRM20001 Lecture 6 Adrenergics, erstellt von Dan McArthur am 30/10/2016.
- Erstellt von
- Dan McArthur
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