HIV

HIV

Single stranded positive RNA. To make DNA

Lentivirus - slow to produce symptoms

Circular enveloped icosahedra capsid.

Outside glycosylated proteins GP120. Also has MHC 1 and 2 molecules from the host.

In nucleocapsidTwo copies of RNA bind to loads of reverse transcriptase integrase and proteins p6 and p7 GAG gene.

P7 AND 7 Prevents breakdown by host nuclease

Outside Nucleocapsid

Viral protease - PROCESSESES long strands of polyproteins into individual genes

Replication

GP120 interacts with host surface proteins. CD4 and then chemokine receptor

Integrase causes integration of DNA into host DNA.

Viral envelope fuses with cell membrane, viral matrix (ONLY CERTAIN VIRUSES) disintegrates. Release of nucleocapsid into cytosol

Stages

Viral capsid uncoats RNA used as template for -DNA. Reverse transcriptase from-DNA to +DNA and create DS dna

dsDNA transported along microtubles to nucleus. Integrase integrates virus into DNA. Becomes a provirus

RNA spliced by enxymes to shorter mRNA to be translated. Others packaged to viral particles. Assemble at plasma membrane in lipid shafts where viral envelope proteins are. Viral particles bud and are released outside cell