NSAIDS

NSAIDS

1. Examples

   • Aspirin
   • Indomethacin
   • Paracetemol
   • Ibuprofen
   • Didofenac

2. Physiologic stimulus

   • COX-1 (constitutive)
     • Location
       • Stomach, Kidney, Intestine, Platelets, Endothelium
         • PGE2
         • TXA2
         • PGI2
         • Essentially physiologic functions

3. Inflammatory Stimulus

   • COX-2 inducible
     • Inflammatory sites (macrophages, syncoviocytes)
       • Inflammatory PG's
       • Proteases
       • O2