T cell activation

T cell activation

1. Adhesion molecules stabilise TCR-MHC interactions.

2. 2-signal hypothesis

   • TCR-MHC Ligation + co-stimulatory signals = Tcell activation
     • Ligation alone causes anergy

3. CD28

   • constitutively expressed by naive T-cells
   • co-stimulatory signals for activation and survival
     • produce interleukins (IL-6)
     • Stimulate against CD3
     • Ab against CD3 and CD28: IL2 production
   • B7 receptor

4. CTLA-4 (ligand)

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