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T cell activation
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T cell activation
Adhesion molecules stabilise TCR-MHC interactions.
2-signal hypothesis
- TCR-MHC Ligation + co-stimulatory signals = Tcell activation
- Ligation alone causes anergy
- TCR-MHC Ligation + co-stimulatory signals = Tcell activation
CD28
- constitutively expressed by naive T-cells
- co-stimulatory signals for activation and survival
- produce interleukins (IL-6)
- Stimulate against CD3
- Ab against CD3 and CD28: IL2 production
- B7 receptor
CTLA-4 (ligand)
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- Mind Map on T cell activation, created by M Sandalo on 30/08/2015.
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- M Sandalo
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